{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:05:33Z","timestamp":1770984333599,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T00:00:00Z","timestamp":1349136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Symptoms of anxiety induced by 7.5% CO<jats:sub>2<\/jats:sub> inhalation can be attenuated by acute administration of GABA<jats:sub>A<\/jats:sub> receptor anxiolytics such as lorazepam and alprazolam. This study investigated if these effects are dose\u2010related, by comparing a 0.5 mg dose (considered non\u2010clinically effective) and a 2 mg dose of lorazepam (clinically effective) on 7.5% CO<jats:sub>2<\/jats:sub> inhalation.<\/jats:p><jats:p>Eighteen healthy males (mean age 20.6\u2009years, <jats:italic>SD<\/jats:italic> 1.29), judged physically and mentally fit, attended three visits, each one week apart, to take each treatment in a randomised double\u2010blind crossover design. Drugs were given 60\u2009min prior to 20\u2009min air inhalation, followed by 20\u2009min 7.5% CO<jats:sub>2<\/jats:sub> inhalation. The order of gas presentation was single blind. Subjective ratings using visual analogue scales (VAS) and questionnaires were recorded before and after each inhalation. Blood pressure (BP), heart rate (HR), respiration rate (RR) and expired CO<jats:sub>2<\/jats:sub> were recorded during each inhalation.<\/jats:p><jats:p>Inhalation of 7.5% CO<jats:sub>2<\/jats:sub> significantly raised BP, HR, RR and expired CO<jats:sub>2<\/jats:sub>. Ratings of feeling like leaving the room were significantly lower on 2\u2009mg compared with 0.5\u2009mg and placebo, and dose\u2010dependent trends were seen in scores for VAS fearful, anxious, stressed, tense, and worried. Results may be indicative of dose\u2010dependent effects of lorazepam in a CO<jats:sub>2<\/jats:sub> model of anxiety. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hup.2261","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T08:23:41Z","timestamp":1349166221000},"page":"540-548","source":"Crossref","is-referenced-by-count":13,"title":["The effect of a clinically effective and non\u2010effective dose of lorazepam on 7.5% CO<sub>2<\/sub>\u2010induced anxiety"],"prefix":"10.1002","volume":"27","author":[{"given":"Alison","family":"Diaper","sequence":"first","affiliation":[{"name":"Psychopharmacology Unit University of Bristol, Academic Unit of Psychiatry  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Psychopharmacology Unit University of Bristol, Academic Unit of Psychiatry  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann S.","family":"Rich","sequence":"additional","affiliation":[{"name":"Psychopharmacology Unit University of Bristol, Academic Unit of Psychiatry  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerry R.","family":"Dawson","sequence":"additional","affiliation":[{"name":"P1vital Ltd, Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin T.","family":"Dourish","sequence":"additional","affiliation":[{"name":"P1vital Ltd, Department of Psychiatry University of Oxford, Warneford Hospital  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Nutt","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Unit, Hammersmith Hospital Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne E.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Severnside Alliance for Translational Research University of Bristol, School of Medical Sciences  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00075-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)57004-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2008.04.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20048"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811030173002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111408455"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881106063889"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111400650"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108089603"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(94)00045-S"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.172.6.465"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988110201600116"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(90)90077-F"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00188-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.104.1.156"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7916(82)90034-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(93)90012-H"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00300-X"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02246029"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01826201"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199312000-00009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881112443742"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105051527"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.8.1120"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000084032.22282.ff"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00160-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800250035006"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.4.493"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105051528"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1988.158"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09020149"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(89)90044-2"},{"key":"e_1_2_7_34_1","volume-title":"British National Formulary","author":"Joint Formulary Committee","year":"2010"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-8194.2004.01158.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820160076009"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050578"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.8.715"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470986844"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810220033004"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(97)00238-2"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108097716"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000125682.97466.3c"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200206000-00011"},{"key":"e_1_2_7_45_1","volume-title":"Anxiety Sensitivity Index revised test manual","author":"Peterson RA","year":"1993"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105056533"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(86)90143-9"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810020059010"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90447-C"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109104864"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110364270"},{"key":"e_1_2_7_52_1","volume-title":"Manual for the State\u2010Trait Anxiety Inventory (Form Y)","author":"Spielberger CD","year":"1983"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000329"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(03)00041-7"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.10.029"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.2261","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.2261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T20:40:13Z","timestamp":1700599213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.2261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,2]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1002\/hup.2261"],"URL":"https:\/\/doi.org\/10.1002\/hup.2261","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,2]]}}}