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Thirty of these individuals were also marijuana (MJ) dependent; 29 were not. Twenty\u2010six socially drinking healthy controls were also recruited. All participants were exposed to three 5\u2010min guided imagery conditions (stress, alcohol\/cocaine cue and relaxing), presented randomly, one per day across three consecutive days. Measures of craving, anxiety, heart rate, blood pressure, plasma adrenocorticotrophic hormone and cortisol were collected at baseline and subsequent recovery time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MJ\u2010dependent group showed increased basal anxiety ratings and cardiovascular output alongside enhanced alcohol craving and cocaine craving, and dampened cardiovascular response to stress and cue. They also demonstrated elevated cue\u2010induced anxiety and stress\u2010induced cortisol and adrenocorticotrophic hormone levels, which were not observed in the non\u2010MJ\u2010dependent group or controls. Cue\u2010related alcohol craving and anxiety were both predictive of a shorter number of days to marijuana relapse following discharge from inpatient treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings provide some support for drug cross\u2010sensitization in terms of motivational processes associated with stress\u2010related and cue\u2010related craving and relapse. 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