{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:20:17Z","timestamp":1770909617665,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,30]],"date-time":"2013-06-30T00:00:00Z","timestamp":1372550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to assess whether a lower initial dose of mirtazapine can lessen the harmful effect on driving performance or not in a double\u2010blinded, placebo\u2010controlled crossover trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen healthy men received 8\u2009days of continuous nocturnal doses of mirtazapine at 7.5\u2009mg or 15\u2009mg, or placebo. At baseline and on days 2 and 9, subjects performed three driving tasks (road\u2010tracking, car\u2010following, and harsh\u2010braking tasks) using a driving simulator and a Continuous Performance Test. Stanford Sleepiness Scale (SSS) scores were also assessed. In the mirtazapine 7.5\u2009mg series, 15\u2009mg of mirtazapine was additionally administered on day 9, followed by all the same assessments on day 10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mirtazapine 7.5\u2009mg had no significant effects on any tasks except for SSS compared with placebo. Mirtazapine 15\u2009mg impaired road\u2010tracking task and SSS. The increase in mirtazapine dose also had no significant effects on any tasks compared with those before dose increase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mirtazapine 7.5\u2009mg did not cause driving impairment compared with mirtazapine 15\u2009mg, while both doses of mirtazapine produced subjective somnolence. The increase in mirtazapine had no detrimental effects on psychomotor performance. Initial low\u2010dose mirtazapine may be safer for automobile driving than the normal starting dose. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2327","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T04:07:09Z","timestamp":1372651629000},"page":"523-528","source":"Crossref","is-referenced-by-count":14,"title":["Effects of low\u2010dose mirtazapine on driving performance in healthy volunteers"],"prefix":"10.1002","volume":"28","author":[{"given":"Kunihiro","family":"Iwamoto","sequence":"first","affiliation":[{"name":"Department of Psychiatry Nagoya University, Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University, Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Sasada","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University, Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Kohmura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University, Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maeri","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University, Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Ebe","sequence":"additional","affiliation":[{"name":"Toyota Central R&amp;D Labs., Inc. 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