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The aim of this study was to evaluate the cardiovascular (CV) effects of 3\u2009weeks of dosing with venlafaxine, pregabalin and placebo on young healthy adults.<\/jats:p><jats:p>Fifty\u2010four participants, of mean age 23.1\u2009years (sd 4.68), 29 male, were randomised into three parallel groups. Each group received one of the three drugs, dosed incrementally over a 3\u2010week period to reach daily doses of 150\u2009mg\/day venlafaxine and 200\u2009mg\/day pregabalin. Blood pressure sphygmomanometer measurements, heart rate measurements, and orthostatic challenges recorded continuously beat\u2010to\u2010beat were performed weekly over this period and 5\u2009days after treatment cessation.<\/jats:p><jats:p>Results showed resting systolic blood pressure (SBP) and resting and standing diastolic blood pressure (DBP) and heart rate (HR) were significantly raised by venlafaxine compared with the pregabalin and placebo groups. SBP drop on standing was larger, the resulting overshoot was smaller, and recovery was slower on venlafaxine. HR recovery was significantly impaired by venlafaxine. CV changes were observed after only 1\u2009week of dosing at 112.5\u2009mg\/day. These effects of venlafaxine are likely to be due to its action of noradrenergic reuptake inhibition. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hup.2346","type":"journal-article","created":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T01:43:04Z","timestamp":1376703784000},"page":"562-575","source":"Crossref","is-referenced-by-count":17,"title":["Changes in cardiovascular function after venlafaxine but not pregabalin in healthy volunteers: a double\u2010blind, placebo\u2010controlled study of orthostatic challenge, blood pressure and heart rate"],"prefix":"10.1002","volume":"28","author":[{"given":"Alison","family":"Diaper","sequence":"first","affiliation":[{"name":"Psychopharmacology Unit University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann S.","family":"Rich","sequence":"additional","affiliation":[{"name":"Psychopharmacology Unit University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue J.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Psychopharmacology Unit University of Bristol  Bristol UK"},{"name":"Neuropsychopharmacology Unit, Division of Experimental Medicine Imperial College London  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Craig","sequence":"additional","affiliation":[{"name":"P1vital Ltd.  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