{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:37:47Z","timestamp":1789936667578,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T00:00:00Z","timestamp":1383523200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Although selective serotonin reuptake inhibitors are now established as first\u2010line pharmacotherapy for social anxiety disorder (SAD), other agents with different mechanisms have shown promise in treating SAD. The aim of this study was to examine the efficacy and safety of tandospirone in treating adolescents with SAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adolescent patients meeting the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM\u2010IV) criteria for SAD were randomly assigned (1:1) to open\u2010label treatment with either tandospirone or sertraline for 8\u2009weeks. The primary outcome measures were changes from baseline in the Hamilton Anxiety (HAM\u2010A) scale and response using the Clinical Global Impression of Improvement (CGI\u2010I) scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The adjusted mean change in HAM\u2010A scores from baseline was indicating a significant improvement over baseline in both treatment arms (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The mean CGI\u2010I scale score at week was with no significant difference between the two arms (<jats:italic>p<\/jats:italic>\u2009=\u20090.42). Rates of response were 48.6% for tandospirone and 55.6% for sertraline using the CGI\u2010I. Response rates were 37.1% for tandospirone and 41.7% for sertraline using a HAM\u2010A response criterion (\u226550% reduction). The adjusted mean change in Social Phobia Inventory scores from baseline was indicating a significant improvement over baseline in both treatment arms (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tandospirone is safe and effective and appears non\u2010inferior to sertraline for SAD in youths. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2361","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T10:59:24Z","timestamp":1383562764000},"page":"594-599","source":"Crossref","is-referenced-by-count":18,"title":["Clinical evaluation of the efficacy and safety of tandospirone versus sertraline monotherapy for social anxiety disorder: a randomized open\u2010label trial"],"prefix":"10.1002","volume":"28","author":[{"given":"Xiao","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Psychological Medicine, Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010hui","family":"Li","sequence":"additional","affiliation":[{"name":"Mental Health Institute The Second Xiangya Hospital of Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010li","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tongji Hospital of Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Science Duke University Medical Center Durham USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010jun","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of South Carolina Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010lin","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707001699"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2000.192"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200105000-00016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.176.4.379"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245588"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0022-3565(25)23815-0","article-title":"Tandospirone and alprazolam: comparison of behavioral effects and abuse liability in humans","volume":"271","author":"Evance SM","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n1102"},{"key":"e_1_2_7_9_1","unstructured":"GuyW.1976.ECDEU assessment manual for psychopharmacology. 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