{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:34:59Z","timestamp":1784954099660,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T00:00:00Z","timestamp":1383523200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We assessed kidney function in long\u2010term lithium\u2010treated bipolar patients compared with age\u2010matched patients not taking lithium, including novel markers of kidney injury such as plasma neutrophil gelatinase\u2010associated lipocalin (NGAL) and urinary beta\u20102 microglobulin (\u03b22\u2010MG)<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study comprised 120 patients with bipolar disorder of which 90 (30 males and 60 females) have been receiving lithium for 5\u201338 (mean 16)\u2009years, and 30 (10 males and 20 females) have never been exposed to lithium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lithium\u2010treated patients, both men and women, showed significantly higher plasma NGAL and urinary \u03b22\u2010MG and lower urine specific gravity and estimated glomerular filtration rate (eGFR), compared with patients not taking lithium. In these patients, serum NGAL did not correlate with any clinical feature or other parameter of kidney function. Urinary \u03b22\u2010MG correlated with serum creatinine and eGFR in the whole group of lithium\u2010treated patients and in addition, in males, with duration of illness, duration of lithium treatment, and urine specific gravity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lithium treatment causes an impairment of kidney function reflected also by abnormal levels of novel markers of kidney injury. Of these, urinary \u03b22\u2010MG, as a marker of tubular function seems to be better predictor than serum NGAL in lithium\u2010treated patients because it shows multiple clinical and biochemical correlations, especially in men. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2362","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T10:59:24Z","timestamp":1383562764000},"page":"615-618","source":"Crossref","is-referenced-by-count":18,"title":["Novel markers of kidney injury in bipolar patients on long\u2010term lithium treatment"],"prefix":"10.1002","volume":"28","author":[{"given":"Janusz K.","family":"Rybakowski","sequence":"first","affiliation":[{"name":"Department of Adult Psychiatry Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Abramowicz","sequence":"additional","affiliation":[{"name":"Department of Adult Psychiatry Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ch\u0142opocka\u2010Wozniak","sequence":"additional","affiliation":[{"name":"Department of Adult Psychiatry Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislaw","family":"Czekalski","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"246","article-title":"Acute kidney injury (AKI) biomarker","volume":"44","author":"Adiyanti SS","year":"2012","journal-title":"Acta Med Indones"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1055\/s-2007-1019635","article-title":"Renal function and biopsy in patients on lithium\u2010therapy","volume":"13","author":"Albrecht J","year":"1980","journal-title":"Pharmakopsychiatr Neuropsychopharmakol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb07013.x"},{"key":"e_1_2_7_5_1","first-page":"1250","article-title":"Kidney damage in long\u2010term lithium patients: a cross\u2010sectional study of patients with 15 years or more on lithium","volume":"9","author":"Bendz H","year":"1994","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(96)00046-8"},{"key":"e_1_2_7_7_1","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis I Disorders, Clinician Version (SCID\u2010CV)","author":"First MB","year":"1996"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.109.463.810"},{"key":"e_1_2_7_9_1","unstructured":"KokotF Hyla\u2010KlekotL KokotS.2011.Badania laboratoryjne. 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