{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:57:47Z","timestamp":1771894667136,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T00:00:00Z","timestamp":1385337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Various genetic polymorphisms have been reported to be associated with antipsychotic\u2010induced weight gain. In this study, we aimed to determine whether risk polymorphisms in 12 candidate genes are associated with reduction in body mass index (BMI) of patients following switching of antipsychotics to aripiprazole or ziprasidone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 115 schizophrenia patients with metabolic abnormalities and who have been on at least 1\u2009year treatment with other antipsychotics; they were then switched to either aripiprazole or ziprasidone. They were genotyped, and their BMI monitored for 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:bold>S<\/jats:bold>ignificant associations with reduction in BMI at 6\u2009months following switching were found in two of these genes: with rs1800544 of the ADRA2A gene (CC\u2009+\u2009CG [\u22120.32\u2009\u00b1\u20091.41\u2009kg\/m<jats:sup>2<\/jats:sup>] vs GG [\u22121.04\u2009\u00b1\u20091.63\u2009kg\/m<jats:sup>2<\/jats:sup>], <jats:italic>p<\/jats:italic>\u2009=\u20090.013) and with rs1801131 of the MTHFR gene (AA [\u22120.36\u2009\u00b1\u20091.53] vs AC\u2009+\u2009CC [\u22121.07\u2009\u00b1\u20091.53], <jats:italic>p<\/jats:italic>\u2009=\u20090.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study data indicated that carriage of the ADRA2A rs1800544 GG genotype and the MTHFR rs1801131 C allele are associated with BMI reduction in this population following switching of antipsychotics to aripiprazole and ziprasidone. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2366","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T03:33:11Z","timestamp":1385436791000},"page":"38-45","source":"Crossref","is-referenced-by-count":14,"title":["Association of ADRA2A and MTHFR gene polymorphisms with weight loss following antipsychotic switching to aripiprazole or ziprasidone"],"prefix":"10.1002","volume":"29","author":[{"given":"Siti Norsyuhada","family":"Roffeei","sequence":"first","affiliation":[{"name":"Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin P.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Biomedical Research Centre Sheffield\u2010Hallam University  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nor Zuraida","family":"Zainal","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mas Ayu","family":"Said","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Hatim","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syarinaz Ahmad","family":"Aida","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahurin","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.11.1686"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e32832c2624"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/55.1.228s"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.5.919"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30554"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111430748"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.10.011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000504"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.04.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.10.010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(99)00083-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2011.68"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(85)90005-X"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.09.030"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2004.03.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402078"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.11.40"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"e_1_2_9_21_1","first-page":"745","article-title":"Regulation of lipolysis in fat cells of obese women during long\u2010term hypocaloric diet","volume":"20","author":"Hellstrom L","year":"1996","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_9_22_1","first-page":"15","article-title":"Association study of energy homeostasis genes and antipsychotic\u2010induced weight gain in patients with schizophrenia","volume":"44","author":"Jassim G","year":"2011","journal-title":"Pharmacopsychiatry"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3181d52b85"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318234ee84"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00186-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.109"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000217972.80731.ef"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.1.3.377"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001556"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.10.002"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/459284"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30311"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2012.10.2.71"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.10.010"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08913-4"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181fbfac4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.00961.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e3282f94905"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.09.43"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2008.01334.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2009.02036.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200504000-00002"},{"key":"e_1_2_9_43_1","first-page":"157","article-title":"Clozapine and weight gain","volume":"55","author":"Umbricht DS","year":"1994","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-005-0291-7"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1998.2714"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e32833bc60d"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.05.030"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e3180582412"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.2366","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.2366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T23:35:32Z","timestamp":1696462532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.2366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,25]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1002\/hup.2366"],"URL":"https:\/\/doi.org\/10.1002\/hup.2366","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,25]]}}}