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The aim of this study was to investigate 12 untreated PLMD patients as compared with 12 normal controls and to measure the acute effects of 0.5 mg ropinirole (Requip<jats:sup>\u00ae<\/jats:sup>) \u2013 a non\u2010ergoline dopamine agonist \u2013 as compared with placebo. In three nights (adaptation, placebo, ropinirole night) objective and subjective sleep and awakening quality were evaluated. In the target variable \u2018periodic leg movements per hour of sleep\u2019 (PLM\/<jats:sub>hTST<\/jats:sub>) PLMD patients showed an increased value of 42\/h (normal 0\u20135\/h) with a greater number of arousals due to periodic leg movements (PLM) in sleep. They further demonstrated an increased number of awakenings, sleep stage S1, S4, stage shifts and decreased S2, but there were no significant differences concerning total sleep time, sleep efficiency (SE), subjective sleep quality and morning measures of mood, drive and drowsiness. However, measures of attention variability, numerical memory, fine motor activity and reaction time performance were impaired. Ropinirole 0.5 mg was shown to significantly improve the index PLM\/<jats:sub>hTST<\/jats:sub> by 64% and arousals due to PLM, increase spontaneous arousals, REM\u2010latency, stage 2 and stage shifts and decrease SREM. In the morning attention variability was attenuated and numerical memory augmented. Thus, ropinirole improved some sleep architecture and early morning measures of performance but specifically all PLM variables, which suggests a dopaminergic pathogenesis in PLMD. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hup.239","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T01:31:55Z","timestamp":1106616715000},"page":"177-187","source":"Crossref","is-referenced-by-count":39,"title":["Sleep laboratory studies in periodic limb movement disorder (PLMD) patients as compared with normals and acute effects of ropinirole"],"prefix":"10.1002","volume":"16","author":[{"given":"M.","family":"Saletu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Anderer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Saletu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Semler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Saletu\u2010Zyhlarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,3,29]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"150","volume-title":"Statistics and Topography in Quantitative EEG","author":"Abt K","year":"1988"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(84)80007-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198702000-00007"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/40.4.419"},{"issue":"2","key":"e_1_2_1_6_1","first-page":"173","article-title":"Scoring rules and examples. 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