{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:50:28Z","timestamp":1781189428850,"version":"3.54.1"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The pharmacological self\u2010management of novel psychoactive substance (NPS)\u2010induced psychopathological consequences represents a fast growing phenomenon. This is facilitated by the frequent sharing of NPS intake experiences online and by the ease of access to a range of psychotropic medications from both the online and street market. Olanzapine is anecdotally reported by Web users to be the most frequent self\u2010prescribed medication to cope with NPS\u2010induced psychoses. Hence, we aimed here at better assessing olanzapine use\/misuse for this purpose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Exploratory qualitative searches of 163 discussion fora\/specialized websites have been carried out in four languages (English, German, Spanish, and Italian) in the time frame November 2012\u20132013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most NPS\u2010users allegedly self administer with olanzapine to manage related psychotic crises\/\u201cbad trips\u201d. This may be typically taken only for a few days, at a dosage range of 5\u201350\u2009mg\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Only a few research studies have formally assessed the effectiveness of olanzapine and indeed of other second\u2010generation antipsychotics to treat NPS\u2010induced psychosis. Olanzapine was suggested here from a range of pro drug websites as being the \u201cideal\u201d molecule to terminate \u201cbad trips\u201d. Health professionals should be informed about the risks related to olanzapine misuse. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2431","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T07:15:45Z","timestamp":1438067745000},"page":"249-254","source":"Crossref","is-referenced-by-count":35,"title":["Olanzapine as the ideal \u201ctrip terminator\u201d? Analysis of online reports relating to antipsychotics' use and misuse following occurrence of novel psychoactive substance\u2010related psychotic symptoms"],"prefix":"10.1002","volume":"30","author":[{"given":"Giuseppe","family":"Valeriani","sequence":"first","affiliation":[{"name":"Department of Neurology and Psychiatry Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"Corazza","sequence":"additional","affiliation":[{"name":"School of Life and Medical Sciences University of Hertfordshire  Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Saverio","family":"Bersani","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry Sapienza University of Rome  Rome Italy"},{"name":"School of Life and Medical Sciences University of Hertfordshire  Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Melcore","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Metastasio","sequence":"additional","affiliation":[{"name":"Norfolk and Suffolk NHS Foundation Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bersani","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Biotechnologies Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Schifano","sequence":"additional","affiliation":[{"name":"School of Life and Medical Sciences University of Hertfordshire  Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.02.2010.2780"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067064"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-002-0366-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1191"},{"issue":"5","key":"e_1_2_8_6_1","first-page":"365","article-title":"Sleep and biorythm disturbances in schizophrenia, mood and anxiety disorders: a review","volume":"47","author":"Bersani FS","year":"2012","journal-title":"Riv Psichiatr"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2013.04.013"},{"key":"e_1_2_8_8_1","unstructured":"Bluelight.ru.2005.How to end an acid trip early? Chlorpromazine?[Internet]. 2005 Oct 10. Retrieved from:http:\/\/www.bluelight.ru\/vb\/archive\/index.php\/t\u2010224802.html"},{"key":"e_1_2_8_9_1","unstructured":"Bluelight.ru.2007.Best compound to abort an LSD experience. [Internet]. 2007 Jun 22. Retrieved from:http:\/\/www.bluelight.ru\/vb\/archive\/index.php\/t\u2010322020.html"},{"key":"e_1_2_8_10_1","unstructured":"Bluelight.ru.2008.Zyprexa\/olanzapine + mushrooms=. [Internet] 2008 May 13. Retrieved from:http:\/\/www.bluelight.ru\/vb\/threads\/376917\u2010Zyprexa\u2010Olanzapine\u2010Mushrooms"},{"key":"e_1_2_8_11_1","unstructured":"Bluelight.ru.2011.Antipsychotic Zyprexa. [Internet] 2011 Mar 9. Retrieved from:http:\/\/www.bluelight.ru\/vb\/archive\/index.php\/t\u2010560177.html"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-12-221"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000085412.08426.08"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.1.124"},{"key":"e_1_2_8_15_1","first-page":"25","article-title":"Novel drugs, novel solutions: exploring the potential of technological tools for prevention of drug abuse","volume":"1","author":"Corazza O","year":"2011","journal-title":"Ital J Addict"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488411796151129"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1242"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2299"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/09638237.2012.682265"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.07.011"},{"key":"e_1_2_8_21_1","unstructured":"Drugs.com.2013.Zyprexa images. [Internet] 2013. Accessed 2013 Nov 13. Retrieved from:http:\/\/www.drugs.com\/zyprexa\u2010images.html"},{"key":"e_1_2_8_22_1","unstructured":"Drugs\u2010Forum.com.2012.Is there a consensus on the best med to abort tryptamines on an emergency?[Internet]. 2012 Feb 1. Retrieved from:http:\/\/www.drugs\u2010forum.com\/forum\/showthread.php?t=205761"},{"key":"e_1_2_8_23_1","unstructured":"Drugs\u2010Forum.com.2013.Threads tagged with olanzapine. [Internet] 2013 Oct 10. Retrieved from:http:\/\/www.drugs\u2010forum.com\/forum\/tags.php?tag=olanzapine"},{"key":"e_1_2_8_24_1","unstructured":"Erowid.org.2006.No recreational value olanzapine. [Internet]. 2006 Mar 24. Retrieved from:http:\/\/www.erowid.org\/experiences\/exp.php?ID=24834"},{"key":"e_1_2_8_25_1","unstructured":"Erowid.org.2007.Mood stabilizers cancel trip mushrooms olanzapine (Zyprexa) & fluoxetine(Prozac). [Internet]. 2007 Aug 29. Retrieved from:http:\/\/www.erowid.org\/experiences\/exp.php?ID=44850"},{"key":"e_1_2_8_26_1","unstructured":"Erowid.org.2012.Olanzapine. [Internet] 2012 Jan 13. Retrieved from:http:\/\/www.erowid.org\/pharms\/olanzapine\/"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2011.00060"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2013.01.006"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.11.010"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/dar.12028"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2012.03.007"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.9.1755-a"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.174.4.366a"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0405-4"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1505.081114"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063972"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2012.709222"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.07.031"},{"issue":"3","key":"e_1_2_8_39_1","first-page":"43","article-title":"A 4\u2010week, double\u2010blind comparison of olanzapine with haloperidol in the treatment of amphetamine psychosis","volume":"88","author":"Leelahanaj T","year":"2005","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2013.06.010"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0897190012465949"},{"issue":"2","key":"e_1_2_8_42_1","first-page":"e218","article-title":"The antidepressant effects of risperidone and olanzapine in bipolar disorder","volume":"11","author":"McIntyre RS","year":"2004","journal-title":"Can J Clin Pharmacol"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2008.04.014"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2007.10399875"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph10104790"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.8.1170a"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e328351a3e0"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b13-00310"},{"issue":"5","key":"e_1_2_8_49_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1089\/cap.2012.0004","article-title":"Synthetic cannabinoid\u2010induced psychosis: two adolescent cases","volume":"22","author":"Oluwabusi OO","year":"2012","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2312"},{"issue":"3","key":"e_1_2_8_51_1","first-page":"121","article-title":"Clozapine, quetiapine and olanzapine among addicted schizophrenic patients: towards testable hypotheses","volume":"18","author":"Potvin S","year":"2003","journal-title":"Int Clin Psychopharmacol"},{"key":"e_1_2_8_52_1","unstructured":"Qualitygenerics.com.2013.Zyprexa. [Internet]. Retrieved from:https:\/\/www.qualitygenerics.com\/zyprexa(accessed 2 December 2013)."},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2007.10400617"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e3180f62d53"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.02.019"},{"issue":"2","key":"e_1_2_8_56_1","first-page":"140","article-title":"Olanzapine in manic\/mixed patients with or without substance abuse","volume":"48","author":"Sani G","year":"2013","journal-title":"Riv Psichiatr"},{"issue":"6","key":"e_1_2_8_57_1","first-page":"394","article-title":"Poisonings resulting from the ingestion of magic mushrooms in Krak\u00f3w","volume":"62","author":"Satora L","year":"2005","journal-title":"Przegl Lek"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.11.035"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/17542860903350888"},{"issue":"2","key":"e_1_2_8_60_1","first-page":"88","article-title":"New drugs of abuse on the Web: the role of the Psychonaut Web mapping project","volume":"45","author":"Schifano F","year":"2010","journal-title":"Riv Psichiatr"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2070-x"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321079"},{"key":"e_1_2_8_63_1","first-page":"182","article-title":"Analysis of online reports on the potential misuse of benzydamine","volume":"48","author":"Schifano F","year":"2013","journal-title":"Riv Psichiatr"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.05.001"},{"key":"e_1_2_8_65_1","unstructured":"Shoomery.org.2002.Zyprexa\u2014how does this effect shrooms?[Internet]. 2002 Aug 23. Retrieved from:http:\/\/www.shroomery.org\/forums\/showflat.php\/Number\/839001"},{"key":"e_1_2_8_66_1","unstructured":"Shoomery.org.2010.Zyprexa\u2014how does this effect shrooms?[Internet] 2010 Feb 22. Retrieved from:http:\/\/www.shroomery.org\/forums\/showflat.php\/Number\/839001"},{"issue":"1","key":"e_1_2_8_67_1","first-page":"65","article-title":"Psychiatric emergencies (part II): psychiatric disorders coexisting with organic diseases","volume":"17","author":"Testa A","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2012.744996"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.413"},{"issue":"3","key":"e_1_2_8_70_1","first-page":"431","article-title":"Psychotic disorders related with chronic use of mephedrone. Case report","volume":"45","author":"Urban M","year":"2011","journal-title":"Psychiatr Pol"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.2431","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.2431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:49:18Z","timestamp":1696405758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.2431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1002\/hup.2431"],"URL":"https:\/\/doi.org\/10.1002\/hup.2431","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}