{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:01:58Z","timestamp":1778691718753,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Nova Program of the Beijing Municipal Science and Technology Commission","award":["2008B59"],"award-info":[{"award-number":["2008B59"]}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"crossref","award":["CMRPG83043"],"award-info":[{"award-number":["CMRPG83043"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"crossref","award":["Project 2041454"],"award-info":[{"award-number":["Project 2041454"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81171270; 30800367; 30770776"],"award-info":[{"award-number":["81171270; 30800367; 30770776"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Institute of Mental Health Research Grant","award":["CRC 249\/2008"],"award-info":[{"award-number":["CRC 249\/2008"]}]},{"name":"the Taiwan Bureau of National Health Insurance","award":["DOH92-NH-1025"],"award-info":[{"award-number":["DOH92-NH-1025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Little is known about the pattern of QT interval (QTc) prolongation in Asian patients with schizophrenia. This study examined trends of QTc prolongation in schizophrenia inpatients in six Asian countries and territories between 2004 and 2008\/2009 and its independent demographic and clinical correlates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Data on 3482 hospitalized schizophrenia patients (2004\u2009=\u20091826 and 2008\/2009\u2009=\u20091656) in six Asian countries and territories were collected by either chart review or interviews during a 1\u2010month period. Patients' sociodemographic and clinical characteristics, prescriptions of psychotropic drugs, and QTc interval were recorded using a standardized protocol and data collection procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of QTc prolongation (&gt;456\u2009ms) was 2.4% in the whole sample, decreasing from 3.1% in 2004 to 1.6% in 2008\/2009 (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) with wide intercountry variations. However, this decreased trend was driven by decreased QTc prolongation detected in China and Hong Kong (both <jats:italic>p<\/jats:italic>\u2010values\u2009&lt;\u20090.05). Multiple logistic regression analysis of the whole sample revealed that patients having more likely to have an illness lasting longer than 5\u2009years and received antipsychotics classified as list\u20101 drugs according to the Arizona Centre for Education and Research on Therapeutics. Compared with 2004, patients in 2008\/2009 were less likely to have QTc prolongation. Thioridazine caused QTc prolongation most frequently (odds ratio (OR) 4.4; 95% confidence interval (CI) 1.2\u201315.2), followed by sulpiride (OR 2.4; 95% CI 1.3\u20134.5), clozapine (OR 2.4; 95% CI 1.4\u20134.2), and chlorpromazine (OR 1.9; 95% CI 1.07\u20133.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Frequency of QTc prolongation was low in Asian patients with schizophrenia. QTc prolongation in schizophrenia decreased in China and Hong Kong between 2004 and 2008\/2009 but increased in Taiwan over the same period, remaining low in the other countries. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2458","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T09:06:41Z","timestamp":1421917601000},"page":"94-99","source":"Crossref","is-referenced-by-count":15,"title":["QTc prolongation in schizophrenia patients in Asia: clinical correlates and trends between 2004 and 2008\/2009"],"prefix":"10.1002","volume":"30","author":[{"given":"Yu\u2010Tao","family":"Xiang","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences University of Macau  Macao Special Administrative Region China"},{"name":"Department of Psychiatry Chinese University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen F. K.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Chinese University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabor S.","family":"Ungvari","sequence":"additional","affiliation":[{"name":"School of Psychiatry &amp; Clinical Neurosciences University of Western Australia  Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph U.","family":"Correll","sequence":"additional","affiliation":[{"name":"Division of Psychiatry Research The Zucker Hillside Hospital, North Shore\u2010Long Island Jewish Health System  Glen Oaks New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly Y. 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M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Ling","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Mental Health Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Taipei City Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mian\u2010Yoon","family":"Chong","sequence":"additional","affiliation":[{"name":"Kaohsiung Chang Gung Memorial Hospital and School of Medicine Chang Gung University  Gueishan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ee\u2010Heok","family":"Kua","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senta","family":"Fujii","sequence":"additional","affiliation":[{"name":"Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Sim","sequence":"additional","affiliation":[{"name":"Institute of Mental Health  Buangkok Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K. 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Medical University UP  Lucknow Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Kee","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Seoul Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pichet","family":"Udomratn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok\u2010Yoon","family":"Chee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Mental Health Tunku Abdul Rahman Institute of Neuroscience, Kuala Lumpur Hospital  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Sartorius","sequence":"additional","affiliation":[{"name":"Association for the Improvement of Mental Health Programs  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chay\u2010Hoon","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naotaka","family":"Shinfuku","sequence":"additional","affiliation":[{"name":"School of Human Sciences Seinan Gakuin University Fukuoka  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n0109"},{"key":"e_1_2_7_3_1","volume-title":"Practice Guideline for the Treatment of Patients with Schizophrenia","author":"APA","year":"1997"},{"key":"e_1_2_7_4_1","unstructured":"AZCERT.2013.QT drug lists by risk groups. 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