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Fifteen (12%) met our predefined criteria for non\u2010response. Non\u2010responders were younger and at baseline had more prominent disorganised symptoms, poorer social and occupational functioning, poorer quality of life for psychological, social and environmental domains, more prominent neurological soft signs (NSS) and lower body mass index. At endpoint, the non\u2010responders were characterised by higher levels of symptomatology in all domains, poorer functional outcome, poorer quality of life and greater cognitive impairments. They also had more prominent NSS and lower body mass index. The strongest predictors of non\u2010response were more prominent baseline NSS and poor early (7\u2009weeks) treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results are consistent with a lower rate of refractoriness to treatment in first\u2010episode schizophrenia compared with multi\u2010episode samples. 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