{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:14:51Z","timestamp":1791357291319,"version":"4.3.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to assess psychiatric patient attitudes towards psychotropic medication and their association with adherence, as well as to identify the factors that influence these attitudes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine hundred and forty nine consecutive psychiatric outpatients categorized as \u201cpharmacophobic\u201d or \u201cpharmacophilic\u201d according to the Drug Attitude Inventory were compared with regard to adherence to prescribed treatment, socio\u2010demographic variables, clinical characteristics, health locus of control, self\u2010efficacy, and psychological reactance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy three per cent of psychiatric outpatients showed a \u201cpharmacophilic\u201d attitude and 15.5% \u201cpharmacophobic\u201d one. Patients' attitudes toward prescribed drug treatment were clearly related to self\u2010reported treatment adherence. The pharmacophobic group registered significant worse adherence than the pharmacophilic patients. Psychiatric patients\u2019 attitudes to drugs were mediated by external health locus of control, cognitive psychological reactance, and self\u2010efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The encouragement of psychiatric patients\u2019 treatment adherence needs to include lack of coercion during prescription, a positive relationship with the prescriber, verbal persuasion, information containing vicarious experience, and the involvement of the patient in treatment decisions. 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