{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:08:59Z","timestamp":1784333339033,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Pharmacological treatments for Tourette syndrome (TS) vary in efficacy between different patients. The evidence base is limited as even high quality controlled studies tend to be of relatively short duration which may lose relevance in clinical usage. Patients are frequently treated with serial agents in the search for efficacy and tolerability. The success of this strategy has not been previously documented. We examined 400 consecutive TS patients seen over a 10\u2010year period, some with a longer prior history in other clinics; 255\/400 (64%) were prescribed medication. We present this heterogeneous cohort in terms of the number of drugs they had tried, and as a proxy measure of some benefit of the last drug used, whether it had been prescribed under our supervision for \u22655\u2009months. The most commonly prescribed medications were aripiprazole (64%), clonidine (40%), risperidone (30%) and sulpiride (29%) with changes in prescribing practises over the period examined. The number of different drugs tried were one (n\u2009=\u2009155), two (n\u2009=\u200969), three (n\u2009=\u200936), four (n\u2009=\u200914), five (n\u2009=\u200915), six (n\u2009=\u20095), seven (n\u2009=\u20092) and eight (n\u2009=\u20091). The data illustrate the difficulty in drug treatment of tics and suggest that even after trials of several agents there is potential benefit in trying further options. Copyright \u00a9 2015 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hup.2495","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T07:56:20Z","timestamp":1440402980000},"page":"435-441","source":"Crossref","is-referenced-by-count":24,"title":["Serial pharmacological prescribing practices for tic management in Tourette syndrome"],"prefix":"10.1002","volume":"30","author":[{"given":"Mena","family":"Farag","sequence":"first","affiliation":[{"name":"St George's, University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy S.","family":"Stern","sequence":"additional","affiliation":[{"name":"St George's, University of London  London UK"},{"name":"Department of Neurology St. George's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Simmons","sequence":"additional","affiliation":[{"name":"St George's, University of London  London UK"},{"name":"Department of Neurology St. George's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Robertson","sequence":"additional","affiliation":[{"name":"St George's, University of London  London UK"},{"name":"Department of Neurology St. George's Hospital  London UK"},{"name":"Department of Psychiatry University of Cape Town  South Africa"},{"name":"Department of Psychiatry University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"DSM\u2010IV\u2010TR 4th Edition Text Revision","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_10_3_1","unstructured":"BlackmanG CavannaAE.2014.Prescribing practices in adults with Tourette syndrome. 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