{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:18:59Z","timestamp":1783790339250,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T00:00:00Z","timestamp":1459036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Only 30% of major depressive disorder (MDD) patients achieve complete remission with a serotonergic antidepressant (selective serotonin reuptake inhibitor). We investigated the potential of serotonin (5\u2010HT) and interleukin\u20106 (IL\u20106) to serve as functional biomarkers of fluoxetine response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum IL\u20106 and 5\u2010HT were measured in 73 MDD patients (39 responders and 34 non\u2010responders) pre\u2010 and 6\u2009weeks post\u2010treatment and in 44 normal controls with ELISA. Fluoxetine and norfluoxetine were measured using LC MS\/MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IL\u20106 levels were significantly higher in MDD patients when compared with controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and 5\u2010HT levels were significantly lower in non\u2010responders compared with controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.0131). Pre\u2010 and post\u2010treatment levels of both biomarkers individually and in combination did not significantly differ between responders and non\u2010responders. Area under the receiver operating characteristics curve for the biomarkers was 0.5. Significant correlation was seen between the percentage change in IL\u20106 and percentage change in Hamilton Rating Scale for Depression score in responders. Fluoxetine and norfluoxetine concentrations were not significantly different in responders and non\u2010responders, and there was no correlation between fluoxetine concentrations and percentage reduction in 5\u2010HT from week 0 to 6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>5\u2010HT and IL\u20106 may not serve as useful markers of response to fluoxetine because of inconsistent results across different studies. Copyright \u00a9 2016 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2525","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T03:42:42Z","timestamp":1459136562000},"page":"178-184","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of interleukin\u20106 and serotonin as biomarkers to predict response to fluoxetine"],"prefix":"10.1002","volume":"31","author":[{"given":"Aarthi","family":"Manoharan","sequence":"first","affiliation":[{"name":"Department of Pharmacology Jawaharlal Institute of Postgraduate Medical Education and Research  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Philip","family":"Rajkumar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Jawaharlal Institute of Postgraduate Medical Education and Research  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak 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