{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:54:25Z","timestamp":1787496865553,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21 DA034095"],"award-info":[{"award-number":["R21 DA034095"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cocaine users display deficits in inhibitory control and make impulsive choices that may increase risky behavior. Buspirone is an anxiolytic that activates dopaminergic and serotonergic systems and improves impulsive choice (i.e., reduces sexual risk\u2010taking intent) in cocaine users when administered chronically. We evaluated the effects of acutely administered buspirone on inhibitory control and impulsive choice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eleven subjects with a recent history of cocaine use completed this within\u2010subject, placebo\u2010controlled study. Subjects performed two cued go\/no\u2010go and a sexual risk delay\u2010discounting task following oral administration of buspirone (10 and 30\u00a0mg), triazolam (0.375\u00a0mg; positive control), and placebo (negative control). Physiological and psychomotor performance and subject\u2010rated data were also collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Buspirone failed to change inhibitory control or impulsive choice; however, slower reaction times were observed at the highest dose tested. Buspirone did not produce subject\u2010rated drug effects but dose\u2010dependently decreased diastolic blood pressure. Triazolam impaired psychomotor performance and increased ratings of positive subject\u2010rated effects (e.g., Like Drug).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that acutely administered buspirone has little impact on behavioral measures of inhibitory control and impulsive sexual decision\u2010making. Considering previous findings with chronic dosing, these findings highlight that the behavioral effects of buspirone differ as a function of dosing conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hup.2567","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T02:36:41Z","timestamp":1485311801000},"source":"Crossref","is-referenced-by-count":13,"title":["Effects of acute buspirone administration on inhibitory control and sexual discounting in cocaine users"],"prefix":"10.1002","volume":"32","author":[{"given":"Justin C.","family":"Strickland","sequence":"first","affiliation":[{"name":"Department of Psychology University of Kentucky Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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