{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:39Z","timestamp":1786977999769,"version":"build-2736575974"},"reference-count":80,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"Sigrid Jus\u00e9lius foundation, Oy H Lundbeck Ab, the Academy of Finland2","award":["#268336"],"award-info":[{"award-number":["#268336"]}]},{"name":"Sigrid Jus\u00e9lius foundation, Oy H Lundbeck Ab, the Academy of Finland2","award":["#278286"],"award-info":[{"award-number":["#278286"]}]},{"DOI":"10.13039\/100010125","name":"Jalmari ja Rauha Ahokkaan S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011935","name":"Northern Finland Health Care Support Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011935","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Psychopharmacol Clin Exp"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1002\/hup.2574","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T01:25:23Z","timestamp":1490837123000},"page":"e2574","source":"Crossref","is-referenced-by-count":76,"title":["Long-term antipsychotic use and brain changes in schizophrenia - a systematic review and meta-analysis"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0292-2581","authenticated-orcid":false,"given":"Sanna","family":"Huhtaniska","sequence":"first","affiliation":[{"name":"Center for Life Course Health Research; University of Oulu; Oulu Finland"},{"name":"Medical Research Center Oulu; Oulu University Hospital and University of Oulu; Oulu Finland"},{"name":"Department of Psychiatry, Research Unit of Clinical Neuroscience; University of Oulu; Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[{"name":"Center for Life Course Health Research; University of Oulu; Oulu Finland"},{"name":"Medical Research Center Oulu; Oulu University Hospital and University of Oulu; Oulu Finland"},{"name":"Department of Psychiatry, Research Unit of Clinical Neuroscience; University of Oulu; Oulu Finland"},{"name":"Department of Psychiatry; Oulu University Hospital; Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noora","family":"Hirvonen","sequence":"additional","affiliation":[{"name":"Information Studies, Faculty of Humanities; University of Oulu; Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Remes","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology; Oulu University Hospital; Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham K.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; University of Cambridge; Cambridge UK"},{"name":"Behavioural and Clinical Neuroscience Institute; University of Cambridge; Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Veijola","sequence":"additional","affiliation":[{"name":"Medical Research Center Oulu; Oulu University Hospital and University of Oulu; Oulu Finland"},{"name":"Department of Psychiatry, Research Unit of Clinical Neuroscience; University of Oulu; Oulu Finland"},{"name":"Department of Psychiatry; Oulu University Hospital; Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Isohanni","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Research Unit of Clinical Neuroscience; University of Oulu; Oulu Finland"},{"name":"Department of Psychiatry; Oulu University Hospital; Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouko","family":"Miettunen","sequence":"additional","affiliation":[{"name":"Center for Life Course Health Research; University of Oulu; Oulu Finland"},{"name":"Medical Research Center Oulu; Oulu University Hospital and University of Oulu; Oulu Finland"},{"name":"Department of Psychiatry, Research Unit of Clinical Neuroscience; University of Oulu; Oulu Finland"},{"name":"Department of Psychiatry; Oulu University Hospital; Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"10.1002\/hup.2574-BIB0001|hup2574-cit-0002","doi-asserted-by":"crossref","unstructured":"Aderhold , V. Weinmann , S. H\u00e4gele , C. Heinz , A 2015 Frontal brain volume reduction due to antipsychotic drugs? [article in German] Nervenarzt 86 302 323 10.1007\/s00115-014-4027-5","DOI":"10.1007\/s00115-014-4027-5"},{"key":"10.1002\/hup.2574-BIB0002|hup2574-cit-0003","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.biopsych.2011.05","article-title":"Progressive brain change in schizophrenia: A prospective longitudinal study of first-episode schizophrenia","volume":"70","author":"Andreasen","year":"2011","journal-title":"Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0003|hup2574-cit-0004","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1176\/appi.ajp.2013.12050674","article-title":"Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: A prospective longitudinal MRI study","volume":"170","author":"Andreasen","year":"2013","journal-title":"The American Journal of Psychiatry"},{"key":"10.1002\/hup.2574-BIB0004|hup2574-cit-0005","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1192\/bjp.bp.107.041467","article-title":"Longitudinal MRI study in schizophrenia patients and their healthy siblings","volume":"193","author":"Brans","year":"2008","journal-title":"The British Journal of Psychiatry"},{"key":"10.1002\/hup.2574-BIB0081|hup2574-cit-0082","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.biopsych.2014.05.023","article-title":"Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk","volume":"77","author":"Cannon","year":"2015","journal-title":"Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0005|hup2574-cit-0006","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.schres.2012.05.002","article-title":"Longitudinal progression of frontal and temporal lobe changes in schizophrenia","volume":"139","author":"Cobia","year":"2012","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0006|hup2574-cit-0007","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"Power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychological Bulletin"},{"key":"10.1002\/hup.2574-BIB0007|hup2574-cit-0008","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.schres.2012.03.036","article-title":"Symptom dimensions are associated with progressive brain volume changes in schizophrenia","volume":"138","author":"Collin","year":"2012","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0008|hup2574-cit-0009","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.schres.2011.11.012","article-title":"An MRI study of septi pellucidi in relation to hippocampus volume and fornix integrity in schizophrenia","volume":"134","author":"Davidson","year":"2012","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0009|hup2574-cit-0010","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.pnpbp.2005.08.019","article-title":"Antipsychotic-associated neuronal changes in the brain: Toxic, therapeutic, or irrelevant to the long-term outcome of schizophrenia?","volume":"30","author":"Dean","year":"2006","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0010|hup2574-cit-0011","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/sj.npp.1300710","article-title":"The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: A comparison of haloperidol and olanzapine in macaque monkeys","volume":"30","author":"Dorph-Petersen","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/hup.2574-BIB0011|hup2574-cit-0012","first-page":"438","article-title":"Volumetric changes in the basal ganglia after antipsychotic monotherapy: A systematic review","volume":"20","author":"Ebdrup","year":"2013","journal-title":"Current Medicinal Chemistry"},{"key":"10.1002\/hup.2574-BIB0012|hup2574-cit-0013","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1016\/j.neubiorev.2013.06.001","article-title":"Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies","volume":"37","author":"Fusar-Poli","year":"2013","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1002\/hup.2574-BIB0014|hup2574-cit-0015","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.neubiorev.2014.03.014","article-title":"A systematic review and meta-analysis of the effects of antipsychotic medications on regional cerebral blood flow (rCBF) in schizophrenia: Association with response to treatment","volume":"43C","author":"Gooz\u00e9e","year":"2014","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1002\/hup.2574-BIB0015|hup2574-cit-0016","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/hbm.22162","article-title":"Key functional circuitry altered in schizophrenia involves parietal regions associated with sense of self","volume":"35","author":"Guo","year":"2014","journal-title":"Human Brain Mapping"},{"key":"10.1002\/hup.2574-BIB0016|hup2574-cit-0017","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.schres.2015.06.016","article-title":"Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function","volume":"168","author":"Guo","year":"2015","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0017|hup2574-cit-0018","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1001\/archpsyc.55.2.145","article-title":"A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures","volume":"55","author":"Gur","year":"1998","journal-title":"Archives of General Psychiatry"},{"key":"10.1002\/hup.2574-BIB0018|hup2574-cit-0019","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1017\/S0033291714000610","article-title":"Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study","volume":"44","author":"Harrow","year":"2014","journal-title":"Psychological Medicine"},{"key":"10.1002\/hup.2574-BIB0019|hup2574-cit-0020","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.schres.2015.06.021","article-title":"Heritability of cortical thickness changes over time in twin pairs discordant for schizophrenia","volume":"173","author":"Hedman","year":"2016","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0020|hup2574-cit-0021","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.schres.2003.08.008","article-title":"Changes in caudate volume after exposure to atypical neuroleptics in patients with schizophrenia may be sex-dependent","volume":"66","author":"Heitmiller","year":"2004","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0021|hup2574-cit-0022","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1002\/hup.2574-BIB0022|hup2574-cit-0023","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archpsyc.60.6.585","article-title":"Progressive structural brain abnormalities and their relationship to clinical outcome: A longitudinal magnetic resonance imaging study early in schizophrenia","volume":"60","author":"Ho","year":"2003","journal-title":"Archives of General Psychiatry"},{"key":"10.1002\/hup.2574-BIB0023|hup2574-cit-0024","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1176\/appi.ajp.2007.05111903","article-title":"Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia","volume":"164","author":"Ho","year":"2007","journal-title":"The American Journal of Psychiatry"},{"key":"10.1002\/hup.2574-BIB0024|hup2574-cit-0025","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1001\/archgenpsychiatry.2010.199","article-title":"Long-term antipsychotic treatment and brain volumes: A longitudinal study of first-episode schizophrenia","volume":"68","author":"Ho","year":"2011","journal-title":"Archives of General Psychiatry"},{"key":"10.1002\/hup.2574-BIB0025|hup2574-cit-0026","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1176\/appi.ajp.162.12.2233","article-title":"Regional deficits in brain volume in schizophrenia: A meta-analysis of voxel-based morphometry studies","volume":"162","author":"Honea","year":"2005","journal-title":"The American Journal of Psychiatry"},{"key":"10.1002\/hup.2574-BIB0026|hup2574-cit-0027","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1093\/schbul\/sbm168","article-title":"What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia","volume":"34","author":"Hulshoff Pol","year":"2008","journal-title":"Schizophrenia Bulletin"},{"key":"10.1002\/hup.2574-BIB0027|hup2574-cit-0028","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.schres.2014.06.035","article-title":"Lifetime use of antipsychotic medication and its relation to change of verbal learning and memory in midlife schizophrenia - an observational 9-year follow-up study","volume":"158","author":"Husa","year":"2014","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0028|hup2574-cit-0029","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1440-1789.2007.00798.x","article-title":"Neuropathology of schizophrenia: A mini review","volume":"27","author":"Iritani","year":"2007","journal-title":"Neuropathology"},{"key":"10.1002\/hup.2574-BIB0029|hup2574-cit-0030","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S0140-6736(76)90890-4","article-title":"Cerebral ventricular size and cognitive impairment in chronic schizophrenia","volume":"2","author":"Johnstone","year":"1976","journal-title":"Lancet"},{"key":"10.1002\/hup.2574-BIB0030|hup2574-cit-0031","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/sj.npp.1301233","article-title":"Effect of chronic exposure to antipsychotic medication on cell numbers in the parietal cortex of macaque monkeys","volume":"32","author":"Konopaske","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/hup.2574-BIB0031|hup2574-cit-0032","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1001\/jamapsychiatry.2015.0712","article-title":"Association of IQ changes and progressive brain changes in patients with schizophrenia","volume":"72","author":"Kubota","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1002\/hup.2574-BIB0032|hup2574-cit-0033","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1017\/S0033291713001712","article-title":"Bilateral hippocampal increase following first-episode psychosis is associated with good clinical, functional and cognitive outcomes","volume":"44","author":"Lappin","year":"2014","journal-title":"Psychological Medicine"},{"key":"10.1002\/hup.2574-BIB0033|hup2574-cit-0034","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1001\/jamapsychiatry.2014.2178","article-title":"A multimodal analysis of antipsychotic effects on brain structure and function in first-episode schizophrenia","volume":"72","author":"Lesh","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1002\/hup.2574-BIB0034|hup2574-cit-0035","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1017\/S0033291709005455","article-title":"Second-generation antipsychotics for schizophrenia: Can we resolve the conflict?","volume":"39","author":"Leucht","year":"2009","journal-title":"Psychological Medicine"},{"key":"10.1002\/hup.2574-BIB0035|hup2574-cit-0036","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/schbul\/sbp099","article-title":"Gray matter in first-episode schizophrenia before and after antipsychotic drug treatment. Anatomical likelihood estimation meta-analyses with sample size weighting","volume":"37","author":"Leung","year":"2011","journal-title":"Schizophrenia Bulletin"},{"key":"10.1002\/hup.2574-BIB0036|hup2574-cit-0037","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1001\/archpsyc.62.4.361","article-title":"Antipsychotic drug effects on brain morphology in first-episode psychosis","volume":"62","author":"Lieberman","year":"2005","journal-title":"Archives of General Psychiatry"},{"key":"10.1002\/hup.2574-BIB0037|hup2574-cit-0038","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0140-6736(76)90984-3","article-title":"Cerebral atrophy and cognitive impairment in chronic schizophrenia","volume":"2","author":"Marsden","year":"1976","journal-title":"Lancet"},{"key":"10.1002\/hup.2574-BIB0038|hup2574-cit-0039","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.schres.2005.06.022","article-title":"Effects of atypical and typical neuroleptics on anterior cingulate volume in schizophrenia","volume":"80","author":"McCormick","year":"2005","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0039|hup2574-cit-0040","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1001\/jamapsychiatry.2013.264","article-title":"Antipsychotic medication during the critical period following remission from first-episode psychosis: Less is more","volume":"70","author":"McGorry","year":"2013","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"10.1002\/hup.2574-BIB0040|hup2574-cit-0041","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1741-7015-2-13","article-title":"A systematic review of the incidence of schizophrenia: The distribution of rates and the influence of sex, urbanicity, migrant status and methodology","volume":"28","author":"McGrath","year":"2004","journal-title":"BMC Medicine"},{"key":"10.1002\/hup.2574-BIB0041|hup2574-cit-0042","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Medicine"},{"key":"10.1002\/hup.2574-BIB0042|hup2574-cit-0043","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1017\/S0033291709992297","article-title":"A systematic review of the effects of antipsychotic drugs on brain volume","author":"Moncrieff","year":"2010","journal-title":"Psychol Med 40"},{"key":"10.1002\/hup.2574-BIB0043|hup2574-cit-0044","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1017\/S0033291709005315","article-title":"Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings","volume":"39","author":"Navari","year":"2009","journal-title":"Psychological Medicine"},{"key":"10.1002\/hup.2574-BIB0044|hup2574-cit-0045","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.schres.2012.10.004","article-title":"A 5-year follow-up study of brain cortical and subcortical abnormalities in a schizophrenia cohort","volume":"142","author":"Nesv\u00e5g","year":"2012","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0045|hup2574-cit-0046","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.biopsych.2011.01.032","article-title":"Are there progressive brain changes in schizophrenia? A meta-analysis of structural magnetic resonance imaging studies","volume":"70","author":"Olabi","year":"2011","journal-title":"Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0046|hup2574-cit-0047","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1016\/j.neubiorev.2012.07.012","article-title":"Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic medication","volume":"36","author":"Radua","year":"2012","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1002\/hup.2574-BIB0047|hup2574-cit-0048","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1017\/S0033291713002365","article-title":"Three-year longitudinal population-based volumetric MRI study in first-episode schizophrenia spectrum patients","volume":"44","author":"Roiz-Santi\u00e1\u00f1ez","year":"2014","journal-title":"Psychological Medicine"},{"key":"10.1002\/hup.2574-BIB0048|hup2574-cit-0049","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2174\/1570159X13666150429002536","article-title":"Brain structural effects of antipsychotic treatment in schizophrenia: A systematic review","volume":"13","author":"Roiz-Santia\u00f1ez","year":"2015","journal-title":"Current Neuropharmacology"},{"key":"10.1002\/hup.2574-BIB0049|hup2574-cit-0050","first-page":"231","volume-title":"The handbook of research synthesis","author":"Rosenthal","year":"1994"},{"key":"10.1002\/hup.2574-BIB0050|hup2574-cit-0051","first-page":"212","volume-title":"Contrasts and effect sizes in behavioral research: A correlational approach","author":"Rosenthal","year":"2000"},{"key":"10.1002\/hup.2574-BIB0051|hup2574-cit-0052","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1440-1819.2001.00783.x","article-title":"Ten year progressive ventricular enlargement in schizophrenia: An MRI morphometrical study","volume":"55","author":"Saijo","year":"2001","journal-title":"Psychiatry and Clinical Neurosciences"},{"key":"10.1002\/hup.2574-BIB0052|hup2574-cit-0053","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.neubiorev.2011.12.015","article-title":"Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia","volume":"36","author":"Shepherd","year":"2012","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1002\/hup.2574-BIB0053|hup2574-cit-0054","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.2174\/138161209788957456","article-title":"The effects of antipsychotics on the brain: What have we learnt from structural imaging of schizophrenia? - a systematic review","volume":"15","author":"Smieskova","year":"2009","journal-title":"Current Pharmaceutical Design"},{"key":"10.1002\/hup.2574-BIB0054|hup2574-cit-0055","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1002\/hup.2574-BIB0055|hup2574-cit-0056","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1038\/mp.2008.34","article-title":"Brain surface contraction mapped in first-episode schizophrenia: A longitudinal magnetic resonance imaging study","volume":"14","author":"Sun","year":"2009","journal-title":"Molecular Psychiatry"},{"key":"10.1002\/hup.2574-BIB0056|hup2574-cit-0057","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.schres.2008.12.029","article-title":"Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia","volume":"108","author":"Takahashi","year":"2009","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0057|hup2574-cit-0058","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.schres.2009.12.006","article-title":"A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia","volume":"119","author":"Takahashi","year":"2010","journal-title":"Schizophrenia Research"},{"key":"10.1002\/hup.2574-BIB0058|hup2574-cit-0059","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1016\/j.pnpbp.2011.07.009","article-title":"A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum","volume":"35","author":"Takahashi","year":"2011a","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0059|hup2574-cit-0060","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.pnpbp.2010.10.023","article-title":"Longitudinal volume changes of the pituitary gland in patients with schizotypal disorder and first-episode schizophrenia","volume":"35","author":"Takahashi","year":"2011b","journal-title":"Prog Neuropsychopharmaco Biol Psychiatry"},{"key":"10.1002\/hup.2574-BIB0060|hup2574-cit-0061","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pscychresns.2011.11.008","article-title":"Longitudinal MRI study of the pituitary volume in chronic schizophrenia: A preliminary report","volume":"202","author":"Takahashi","year":"2012","journal-title":"Psychiatry Research"},{"key":"10.1002\/hup.2574-BIB0061|hup2574-cit-0062","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.pnpbp.2012.10.001","article-title":"Altered depth of the olfactory sulcus in first-episode schizophrenia","volume":"40","author":"Takahashi","year":"2013b","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0062|hup2574-cit-0063","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.pscychresns.2012.12.001","article-title":"Longitudinal MRI study of the midline brain regions in first-episode schizophrenia","volume":"212","author":"Takahashi","year":"2013a","journal-title":"Psychiatry Research"},{"key":"10.1002\/hup.2574-BIB0063|hup2574-cit-0064","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jns.2013.12.025","article-title":"Integrative parietal cortex processes: Neurological and psychiatric aspects","volume":"338","author":"Teixeira","year":"2014","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1002\/hup.2574-BIB0064|hup2574-cit-0065","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1124\/jpet.106.106047","article-title":"Time-dependent cognitive deficits associated with first and second generation antipsychotics: Cholinergic dysregulation as a potential mechanism","volume":"320","author":"Terry","year":"2007","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1002\/hup.2574-BIB0065|hup2574-cit-0066","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1186\/1471-244X-13-342","article-title":"Structural brain changes associated with antipsychotic treatment in schizophrenia as revealed by voxel-based morphometric MRI: An activation likelihood estimation meta-analysis","volume":"13","author":"Torres","year":"2013","journal-title":"BMC Psychiatry"},{"key":"10.1002\/hup.2574-BIB0066|hup2574-cit-0067","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1038\/nn.2572","article-title":"Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits","volume":"13","author":"Tost","year":"2010","journal-title":"Nature Neuroscience"},{"key":"10.1002\/hup.2574-BIB0067|hup2574-cit-0068","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"NeuroImage"},{"key":"10.1002\/hup.2574-BIB0068|hup2574-cit-0069","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/sj.npp.1301347","article-title":"Focal gray matter changes in schizophrenia across the course of the illness: A 5-year follow-up study","volume":"32","author":"Haren","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1002\/hup.2574-BIB0069|hup2574-cit-0070","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.biopsych.2007.01.004","article-title":"Progressive brain volume loss in schizophrenia over the course of the illness: Evidence of maturational abnormalities in early adulthood","volume":"63","author":"Haren","year":"2008","journal-title":"Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0070|hup2574-cit-0071","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1001\/archgenpsychiatry.2011.88","article-title":"Changes in cortical thickness during the course of illness in schizophrenia","volume":"68","author":"Haren","year":"2011","journal-title":"Archives of General Psychiatry"},{"key":"10.1002\/hup.2574-BIB0071|hup2574-cit-0072","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1016\/j.neubiorev.2012.09.006","article-title":"Confounders of excessive brain volume loss in schizophrenia","volume":"37","author":"Haren","year":"2013","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1002\/hup.2574-BIB0072|hup2574-cit-0073","doi-asserted-by":"publisher","first-page":"e101689","DOI":"10.1371\/journal.pone.0101689","article-title":"Longitudinal changes in total brain volume in schizophrenia: Relation to symptom severity, cognition and antipsychotic medication","volume":"9","author":"Veijola","year":"2014","journal-title":"PloS One"},{"key":"10.1002\/hup.2574-BIB0073|hup2574-cit-0074","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.eurpsy.2008.12.007","article-title":"Trends in costs of antipsychotics in France","volume":"24","author":"Verdoux","year":"2009","journal-title":"European Psychiatry"},{"key":"10.1002\/hup.2574-BIB0074|hup2574-cit-0075","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.biopsych.2010.11.010","article-title":"Effect of chronic antipsychotic treatment on brain structure: A serial magnetic resonance imaging study with ex vivo and postmortem confirmation","volume":"69","author":"Vernon","year":"2011","journal-title":"Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0075|hup2574-cit-0076","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.biopsych.2011.12.004","article-title":"Contrasting effects of haloperidol and lithium on rodent brain structure: A magnetic resonance imaging study with postmortem confirmation","volume":"71","author":"Vernon","year":"2012","journal-title":"Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0076|hup2574-cit-0077","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.biopsych.2015.02.008","article-title":"The effect of antipsychotic treatment on cortical gray matter changes in schizophrenia: Does the class matter? A meta-analysis and meta-regression of longitudinal magnetic resonance imaging studies","volume":"78","author":"Vita","year":"2015","journal-title":"Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0077|hup2574-cit-0078","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.biopsych.2008.08.007","article-title":"Progressive deformation of deep brain nuclei and hippocampal-amygdala formation in schizophrenia","volume":"64","author":"Wang","year":"2008","journal-title":"Biological Psychiatry"},{"key":"10.1002\/hup.2574-BIB0078|hup2574-cit-0079","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1176\/ajp.156.8.1200","article-title":"Change in basal ganglia volume over 2\u00a0years in patients with schizophrenia: Typical versus atypical neuroleptics","volume":"156","author":"Westmoreland Corson","year":"1999","journal-title":"The American Journal of Psychiatry"},{"key":"10.1002\/hup.2574-BIB0079|hup2574-cit-0080","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1093\/schbul\/sbm149","article-title":"Progressive changes in the development toward schizophrenia: Studies in subjects at increased symptomatic risk","volume":"34","author":"Wood","year":"2008","journal-title":"Schizophrenia Bulletin"},{"key":"10.1002\/hup.2574-BIB0080|hup2574-cit-0081","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1001\/jamapsychiatry.2013.19","article-title":"Recovery in remitted first-episode psychosis at 7\u00a0years of follow-up of an early dose reduction\/discontinuation or maintenance treatment strategy: Long-term follow-up of a 2-year randomized clinical trial","volume":"70","author":"Wunderink","year":"2013","journal-title":"JAMA Psychiatry"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.2574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/hup.2574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T05:57:32Z","timestamp":1719122252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.2574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":80,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"URL":"https:\/\/doi.org\/10.1002\/hup.2574","archive":["Portico"],"relation":{},"ISSN":["0885-6222"],"issn-type":[{"value":"0885-6222","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}