{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:39:37Z","timestamp":1758476377836,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["094849\/Z\/10\/Z"],"award-info":[{"award-number":["094849\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC\u2010A656\u20105QD30"],"award-info":[{"award-number":["MC\u2010A656\u20105QD30"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2016R1E1A1A02921618"],"award-info":[{"award-number":["2016R1E1A1A02921618"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Early\u2010onset obsessive\u2013compulsive disorder (EOCD) and late\u2010onset obsessive\u2013compulsive disorder (LOCD) are distinct subtypes of obsessive\u2013compulsive disorder (OCD). OCD patients are treated with serotonin reuptake inhibitors, but the difference in serotonin transporter (SERT) availability between medicated EOCD and LOCD is unexplored yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six EOCD and 6 LOCD patients were enrolled. They underwent serial [<jats:sup>11<\/jats:sup>C]DASB positron emission tomography scans during maintenance therapy with escitalopram, and their plasma concentration of escitalopram was measured simultaneously with the scan. Then, the drug\u2010free binding potential of SERT was calculated by pharmacokinetic\u2013pharmacodynamic modelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison with LOCD patients, SERT availability was significantly higher in the putamen of EOCD patients (<jats:italic>U<\/jats:italic>\u00a0=\u00a04, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.026), but not in the caudate nucleus (<jats:italic>U<\/jats:italic>\u00a0=\u00a014, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.589), thalamus (<jats:italic>U<\/jats:italic>\u00a0=\u00a016, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.818), and dorsal raphe nucleus (<jats:italic>U<\/jats:italic>\u00a0=\u00a07, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.093). Binding potential of putamen showed a negative correlation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.580, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.048) with age of onset of the disease, but not with the Yale\u2013Brown Obsessive Compulsive Scale scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings indicate that the earlier the age of onset of OCD, the less serotonergic pathology there is and that this difference remains even after long\u2010term serotonin reuptake inhibitor treatment. Clinically, it might suggest that nonserotonergic treatments would be a better option for EOCD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2642","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T09:16:35Z","timestamp":1512551795000},"source":"Crossref","is-referenced-by-count":12,"title":["Higher serotonin transporter availability in early\u2010onset obsessive\u2013compulsive disorder patients undergoing escitalopram treatment: A [<sup>11<\/sup>C]DASB PET study"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4327-1911","authenticated-orcid":false,"given":"Junhee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2010Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics, College of Medicine Kyung Hee University Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Euitae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine Seoul National University  Seoul Republic of Korea"},{"name":"Department of Neuropsychiatry Seoul National University Bundang Hospital  Seongnam Gyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver D.","family":"Howes","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"},{"name":"MRC Clinical Sciences Centre  London UK"},{"name":"Institute of Clinical Sciences, Faculty of Medicine Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang Ik Kevin","family":"Cho","sequence":"additional","affiliation":[{"name":"Institute of Human Behavioral Medicine SNU\u2010MRC  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngwoo Bryan","family":"Yoon","sequence":"additional","affiliation":[{"name":"Institute of Human Behavioral Medicine SNU\u2010MRC  Seoul Republic of Korea"},{"name":"Department of Brain and Cognitive Sciences, College of Natural Sciences Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Soo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Psychiatry, College of Medicine Seoul National University  Seoul Republic of Korea"},{"name":"Institute of Human Behavioral Medicine SNU\u2010MRC  Seoul Republic of Korea"},{"name":"Department of Brain and Cognitive Sciences, College of Natural Sciences Seoul National University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00004714-199408000-00004","article-title":"Predictors of treatment response in obsessive\u2013compulsive disorder: Multivariate analyses from a multicenter trial of clomipramine","volume":"14","author":"Ackerman D. 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