{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:33Z","timestamp":1753869273130,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of our study was to examine the association between <jats:italic>ABCB1<\/jats:italic> polymorphisms G2677T\/A (rs2032582) and C3435T (rs1045642) and common <jats:italic>CYP2D6<\/jats:italic> variants, with the response to antipsychotic treatment of psychotic patients, in a naturalistic setting, in Greece.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred patients suffering from schizophrenia and other psychotic disorders were included in the study. Dosages were normalized to chlorpromazine equivalents. Response following 1\u00a0month of treatment was assessed as either a continuous variable, using the distribution of the corrected Positive and Negative Syndrome Scale percent change, or as a dichotomous variable defined as the number of patients scoring \u226530% from the corrected baseline Positive and Negative Syndrome Scale score. Genotyping was achieved with established polymerase chain reaction\u2013restriction fragment length polymorphism methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With response treated as a continuous variable, the homozygous recessive rs2032582 genotypes (TT) who were simultaneously carriers of a loss\u2010of\u2010function <jats:italic>CYP2D6<\/jats:italic> allele (*4 or *5) responded significantly worse than the rest of the patients. Comparison of genotype frequencies revealed a statistically significant association of the above combination. No significant association between chlorpromazine equivalents and the tested genotypes was detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have detected a possible interaction between <jats:italic>ABCB1<\/jats:italic> and <jats:italic>CYP2D6<\/jats:italic> in affecting response of psychotic patients to drug treatment, in a naturalistic setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2644","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T05:12:45Z","timestamp":1513573965000},"source":"Crossref","is-referenced-by-count":5,"title":["ABCB1 and CYP2D6 polymorphisms and treatment response of psychotic patients in a naturalistic setting"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1641-9095","authenticated-orcid":false,"given":"Georgios","family":"Papazisis","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonios","family":"Goulas","sequence":"additional","affiliation":[{"name":"1st Department of Pharmacology, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexios","family":"Sarrigiannidis","sequence":"additional","affiliation":[{"name":"2nd University Department of Psychiatry, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavroula","family":"Bargiota","sequence":"additional","affiliation":[{"name":"2nd University Department of Psychiatry, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diomidis","family":"Antoniadis","sequence":"additional","affiliation":[{"name":"2nd University Department of Psychiatry, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Raikos","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanouela","family":"Basgiouraki","sequence":"additional","affiliation":[{"name":"1st Department of Pharmacology, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios P.","family":"Bozikas","sequence":"additional","affiliation":[{"name":"1st University Department of Psychiatry, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Garyfallos","sequence":"additional","affiliation":[{"name":"2nd University Department of Psychiatry, Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2011.35"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(13)71513-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000135"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2014.08.003"},{"issue":"6","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1055\/s-0042-108202","article-title":"One\u2010year follow\u2010up of children and adolescents with major depressive disorder: Relationship between clinical variables and ABCB1 gene polymorphisms","volume":"49","author":"Blazquez A.","year":"2016","journal-title":"Pharmacopsychiatry"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328363a9bf"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2003.01212.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.09.51"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"issue":"2","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1158\/0008-5472.CAN-13-2064","article-title":"MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer","volume":"74","author":"Fung K. 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