{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:47:57Z","timestamp":1790005677050,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003400","name":"Ministry of Research, Innovation and Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003248","name":"Ontario Mental Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      A recent genome\u2010wide association study (GWAS) in obsessive\u2013compulsive disorder (OCD) reported a significant marker in the dispatched homolog 1 (Drosophila) gene (\n                      <jats:italic>DISP1<\/jats:italic>\n                      gene) associated with serotonin reuptake inhibitor (SRI) antidepressant response (Qin et al.,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#hup2659-bib-0037\"\/>\n                      ).\n                      <jats:italic>DISP1<\/jats:italic>\n                      has never been examined before in terms of association with SRI response until this GWAS. We attempt to replicate the GWAS finding by investigating the association of the\n                      <jats:italic>DISP1<\/jats:italic>\n                      rs17162912 polymorphism with SRI response in our sample of 112 European Caucasian OCD patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients were previously treated naturalistically with up to 6 different SRIs sequentially, including 5 selective SRIs (fluoxetine, fluvoxamine, sertraline, paroxetine, and citalopram) and 1 SRI (clomipramine). Each medication trial was evaluated retrospectively for response and was rated categorically as either responder or nonresponder using the Clinical Global Impression\u2013Improvement scale. Fisher's exact test was used to investigate the relationship between the\n                      <jats:italic>DISP1<\/jats:italic>\n                      rs17162912 genotype distribution and SRI response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We did not observe a significant association between rs17162912 and SRI response (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.32).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This replication study did not support the role of\n                      <jats:italic>DISP1<\/jats:italic>\n                      in predicting SRI response in OCD; however, methodological differences between the original GWAS and our study, as well as limited power and low minor allele frequency, may have hindered replication.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hup.2659","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T16:29:42Z","timestamp":1530203382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pharmacogenetic evaluation of a\n                    <i>DISP1<\/i>\n                    gene variant in antidepressant treatment of obsessive\u2013compulsive disorder"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8359-9984","authenticated-orcid":false,"given":"Amanda J.","family":"Lisoway","sequence":"first","affiliation":[{"name":"Molecular Brain Science Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Institute of Medical Science Faculty of Medicine, University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwyneth","family":"Zai","sequence":"additional","affiliation":[{"name":"Molecular Brain Science Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Mood and Anxiety Division Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K.","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Molecular Brain Science Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement C.","family":"Zai","sequence":"additional","affiliation":[{"name":"Molecular Brain Science Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto ON Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Wigg","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Faculty of Medicine, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Goncalves","sequence":"additional","affiliation":[{"name":"Molecular Brain Science Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Molecular Brain Science Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Freeman","sequence":"additional","affiliation":[{"name":"Molecular Brain Science Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Molecular Brain Science Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Institute of Medical Science Faculty of Medicine, University of Toronto  Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto ON Canada"},{"name":"Department of Pharmacology &amp; 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