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They completed a continuous performance task and self\u2010reported their withdrawal symptoms at baseline and twice following a medication titration period: once in a tobacco\u2010deprived state and again in a nondeprived state. Ability to resist smoking was assessed using a laboratory smoking\u2010lapse paradigm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants showed poorer cognitive performance on most measures taken from the continuous performance task when tobacco deprived. Eight\u2010mg\/day doxazosin improved inhibitory control during the nondeprivation session but did not affect sustained attention or reaction time. Participants receiving doxazosin reported fewer withdrawal symptoms during deprivation than those on placebo. Those showing the greatest improvement of inhibitory control under doxazosin were better able to resist smoking (i.e., latency to smoke) during a smoking lapse task. Self\u2010reported withdrawal symptoms also were negatively associated with time to smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Doxazosin reduced symptoms of tobacco withdrawal according to self\u2010report and cognitive assessment and improved inhibitory control above predrug levels. This research identifies potential mechanisms by which doxazosin might improve smoking outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2660","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T19:14:48Z","timestamp":1527794088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A preliminary investigation into the effects of doxazosin on cognitive functioning in tobacco\u2010deprived and \u2010satiated smokers"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6817-884X","authenticated-orcid":false,"given":"Walter","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terril L.","family":"Verplaetse","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay M.","family":"Oberleitner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry A.","family":"McKee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2648"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.01.027"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.034"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2014.908180"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.11.024"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00138-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1970-0"},{"key":"e_1_2_8_9_1","volume-title":"The Conners continuous performance test\u2014Second edition","author":"Conners C. 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