{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:34Z","timestamp":1753869274514,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Long\u2010acting injectable (LAI) aripiprazole is recommended to be combined with oral aripiprazole for 2\u00a0weeks after its introduction. However, we often experience patients who require more than 2\u00a0weeks of combined use. Therefore, differences in combination periods need to be examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a case\u2013control study. We surveyed prescription profiles for oral aripiprazole administration in conjunction with LAI aripiprazole introduction and assessed the clinical course during a 12\u2010week follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 121 patients, 58 (47.9%) were administered both oral and LAI aripiprazole for more than 2\u00a0weeks. Although there was no significant difference in treatment failure (defined as psychiatric hospitalization or discontinuation of LAI aripiprazole from any cause) between the two groups, the group that was administered oral aripiprazole for more than 2\u00a0weeks received less additional benzodiazepines compared with that of the 2\u00a0weeks group (adjusted odds ratio, 0.055; 95% confidence interval [0.0060, 0.50]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data support a flexible co\u2010administration period for oral and LAI aripiprazole in consideration of the pharmacokinetics, but further studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2681","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T12:16:13Z","timestamp":1543320973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effects of different periods of co\u2010administration of oral and long\u2010acting injectable aripiprazole: A propensity score analysis"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7032-878X","authenticated-orcid":false,"given":"Masakazu","family":"Hatano","sequence":"first","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine  Toyoake Japan"},{"name":"Department of Clinical Pharmacy Fujita Health University School of Medicine  Toyoake Japan"},{"name":"Office of Clinical Pharmacy Practice and Health Care Management, Faculty of Pharmacy Meijo University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kamei","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine  Toyoake Japan"},{"name":"Office of Clinical Pharmacy Practice and Health Care Management, Faculty of Pharmacy Meijo University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ippei","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Office of Clinical Pharmacy Practice and Health Care Management, Faculty of Pharmacy Meijo University  Nagoya Japan"},{"name":"Department of Psychiatry Okehazama Hospital  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Tozawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kyowa Hospital  Obu 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