{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:45:36Z","timestamp":1771001136130,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This randomized controlled study evaluated the efficacy of low\u2010dose (LD) and high\u2010dose (HD) aripiprazole augmentation in major depressive disorder. Additionally, we examined the relationship between clinical response and changes in plasma homovanillic acid (pHVA) levels during aripiprazole augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one patients with inadequate response to antidepressants were randomized to receive adjunctive treatment with LD (3\u00a0mg\/day, <jats:italic>n<\/jats:italic>\u00a0=\u00a017) or HD (up to 12\u00a0mg\/day, <jats:italic>n<\/jats:italic>\u00a0=\u00a014) aripiprazole for 6\u00a0weeks. We evaluated the Montgomery\u2013\u00c5sberg Depression Rating Scale (MADRS) and measured pHVA at baseline, Week 2, and end point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both LD and HD aripiprazole significantly decreased MADRS score after 6\u00a0weeks, and the response rate was higher in HD aripiprazole group at end point. HD aripiprazole significantly decreased MADRS score at Week 2 compared with LD aripiprazole (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.015). There was a significant difference in changes in pHVA between responders and nonresponders, showing pHVA decreased significantly in responders at Week 2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increasing aripiprazole from the early period appeared useful for immediate response, although caution is needed when increasing the dose &gt;6\u00a0mg\/day. pHVA may be a possible indicator of the response to aripiprazole augmentation. Caution is needed in interpreting these findings because of the small sample size.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2696","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T05:29:59Z","timestamp":1556774999000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Low\u2010 and high\u2010dose aripiprazole augmentation and plasma levels of homovanillic acid in major depressive disorder: A randomized, open\u2010label study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-1174","authenticated-orcid":false,"given":"Sho","family":"Horikoshi","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itaru","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry 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