{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T19:07:40Z","timestamp":1772564860379,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18dk0307075"],"award-info":[{"award-number":["JP18dk0307075"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18dk0307081"],"award-info":[{"award-number":["JP18dk0307081"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS\/AO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma levels of 28 neuroinflammation\u2010related molecules were determined in 44 controls and 48 BMS\/AO patients both pretreatment and 12\u2010week post\u2010treatment with duloxetine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline plasma levels of interleukin (IL)\u20101\u03b2 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), IL\u20101 receptor antagonist (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), IL\u20106 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), macrophage inflammatory protein\u20101\u03b2 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001), and platelet\u2010derived growth factor\u2010bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein\u20101, and vascular endothelial growth factor decreased significantly with treatment (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001, .022, and .029, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inflammatory mechanisms may be involved in the pathophysiology and\/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2698","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T14:07:11Z","timestamp":1558706831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of antidepressant treatment on plasma levels of neuroinflammation\u2010associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-6806","authenticated-orcid":false,"given":"Tomoya","family":"Miyauchi","sequence":"first","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry Aichi Gakuin University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Umemura","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry Aichi Gakuin University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiji","family":"Sato (Boku)","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Aichi Gakuin University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Psychopathology and Psychotherapy\/Center for Student Counseling Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tonoike","sequence":"additional","affiliation":[{"name":"Faculty of Psychological and Physical Sciences, Health Service Center Aichi Gakuin University Nisshin Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Disease Control Prevention Fujita Health University, Graduate School of Health Sciences Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniaki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Disease Control Prevention Fujita Health University, Graduate School of Health Sciences Toyoake Japan"},{"name":"Advanced Diagnostic System Research Laboratory Fujita Health University, Graduate School of Health Sciences and Aino University Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry Aichi Gakuin University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.12.002"},{"key":"e_1_2_7_3_1","unstructured":"American Psychiatric Association. 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