{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:46:20Z","timestamp":1775688380575,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2018JJ3829"],"award-info":[{"award-number":["2018JJ3829"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570533"],"award-info":[{"award-number":["81570533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate correlation of peripheral blood cell counts with the dyslipidemia induced by olanzapine or clozapine in Chinese schizophrenia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 703 eligible schizophrenia patients were enrolled . The counts of red blood cell (RBC), platelet, white blood cell (WBC) and its subtypes, and serum lipids were determined for all participants before and after 2\u20134\u00a0weeks of olanzapine or clozapine treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two representative second\u2010generation antipsychotics (SGAs), olanzapine and clozapine, markedly caused dyslipidemia in Chinese schizophrenia patients. The tertiles of total RBC counts were positively associated with the odds of having abnormal triglyceride (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) and high\u2010density lipoprotein cholesterol (HDL\u2010C) levels (.05). The tertiles of platelet counts were also positively associated with the odds of having abnormal total cholesterol (.03), low\u2010density lipoprotein cholesterol (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), HDL\u2010C (.01), and non\u2010HDL\u2010C (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). However, the counts of WBC and its some subtypes were negatively correlated with the risk of dyslipidemia in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The profile of peripheral blood cells may be an early biomarker for predicting the risk of metabolic disorders and cardiovascular diseases in schizophrenia patients treated with SGAs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2699","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T03:19:42Z","timestamp":1562296782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of blood cell counts with the risk of olanzapine\u2010 or clozapine\u2010induced dyslipidemia in <scp>Chinese<\/scp> schizophrenia patients"],"prefix":"10.1002","volume":"34","author":[{"given":"Zongping","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Xiangya Hospital, Central South University  Changsha 410008 P. R. China"},{"name":"Institute of Clinical Pharmacology Central South University, Hunan Key Laboratory of Pharmacogenetics  110 Xiangya Road Changsha 410078 P. R. China"},{"name":"Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education  110 Xiangya Road Changsha 410078 P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders  87 Xiangya Road Changsha 410008 Hunan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Hunan Brain Hospital  Changsha 410007 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Xiangya Hospital, Central South University  Changsha 410008 P. R. 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