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There were no medication effects on subjective craving. In high\u2010dose baclofen participants only, there was a predictive effect of lower baseline heart rate variability and fewer post\u2010test percentage of heavy drinking days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a dose\u2010specific rescuing effect of high\u2010dose baclofen on the dynamic modulation of cardiovascular responses to eliciting cues. Investigation of treatment responses using psychophysiological techniques may elucidate baclofen's mechanisms of action, and identify subgroups amenable to treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2722","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T19:23:46Z","timestamp":1581449026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Baclofen modulates cardiovascular responses to appetitive cues in treatment\u2010seeking alcohol use disorder individuals"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0777-3033","authenticated-orcid":false,"given":"Warren B.","family":"Logge","sequence":"first","affiliation":[{"name":"Discipline of Addiction Medicine, Central Clinical School, Faculty of Medicine and Health University of Sydney  New South Wales Australia"},{"name":"Drug Health Services Royal Prince Alfred Hospital  New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Baillie","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Sydney  New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Haber","sequence":"additional","affiliation":[{"name":"Discipline of Addiction Medicine, Central Clinical School, Faculty of Medicine and Health University of Sydney  New South Wales Australia"},{"name":"Drug Health Services Royal Prince Alfred Hospital  New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten C.","family":"Morley","sequence":"additional","affiliation":[{"name":"Discipline of Addiction Medicine, Central Clinical School, Faculty of Medicine and Health University of Sydney  New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/37.5.504"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61814-5"},{"key":"e_1_2_9_4_1","unstructured":"ADInstruments. 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