{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:42:07Z","timestamp":1769517727601,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313821"],"award-info":[{"award-number":["2018A030313821"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A0303130074"],"award-info":[{"award-number":["2018A0303130074"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aimed to investigate the influence of diagnosis, body weight, sex, age, smoking, formulations, and concomitant drugs on steady\u2010state dose\u2010corrected serum concentrations (C\/D) of venlafaxine (VEN) and <jats:italic>O<\/jats:italic>\u2010desmethylvenlafaxine (ODV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of therapeutic drug monitoring (TDM) was carried out. Patients' demographic data, therapeutic regimens, and concentrations were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 91 verified samples from 80 patients. Females had by average 13% smaller body weight, 50% higher C\/D of VEN, and VEN\u2009+\u2009ODV and 25% smaller ODV\/VEN than males. Patients &gt;60\u2009years had by average 33\u201359% higher C\/D levels of ODV and VEN\u2009+\u2009ODV than younger patients. The concomitant use of valproic acid caused an average 51% higher C\/D of ODV and a 2.2\u2010fold larger ODV\/VEN, while clozapine was related with 40% smaller ratio of ODV\/VEN and 38% lower C\/D levels of ODV. Positive correlations were detected between valproic acid concentrations and the C\/D of VEN and VEN\u2009+\u2009ODV. In a multiple linear regression analysis, variance in the C\/D of VEN\u2009+\u2009ODV was partly attributed to the daily dose of VEN, sex, age and valproic acid concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggested daily dose of VEN, sex, age, and valproic acid as indicators for the C\/D of VEN\u2009+\u2009ODV in Chinese patients. TDM as a valuable tool was suggested in elderly female patients and patients receiving polypharmacy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2733","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T11:18:41Z","timestamp":1585826321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of venlafaxine dosage, valproic acid concentration, sex, and age on steady state dose\u2010corrected concentrations of venlafaxine and <scp><i>O<\/i><\/scp>\u2010desmethylvenlafaxine: A retrospective analysis of therapeutic drug monitoring data in a Chinese population"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-7312","authenticated-orcid":false,"given":"Zhan\u2010zhang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010hua","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao\u2010yang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010qing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010qing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan\u2010shan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010qing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010yan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010guan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De\u2010wei","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)  Guangzhou China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.22.16.1500.33697"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00113-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.10.033"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-116492"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000268"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0706743716659416"},{"key":"e_1_2_9_9_1","first-page":"14","article-title":"Short\u2010term efficacy and tolerability of venlafaxine extended release in adults with generalized anxiety disorder without depression: A meta\u2010analysis","volume":"12","author":"Li X. Y.","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000144894.37611.0a"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12796"},{"key":"e_1_2_9_12_1","first-page":"53","article-title":"Simultaneous determination the concentration of risperidone, paliperidone, olanzapine and quetiapine in human serum by HPLC\u2010MS\/MS","volume":"34","author":"Ni X.","year":"2018","journal-title":"Chinese Journal of Clinical Pharmacology"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.11.046"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.04.014"},{"key":"e_1_2_9_15_1","unstructured":"People's Republic of China. (2018). Law on the protection of the rights and interests of elderly people."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200208000-00014"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1996.tb00180.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.2.290"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000234"},{"key":"e_1_2_9_20_1","first-page":"1078","article-title":"Effect of antipsychotic drugs on human liver cytochrome P\u2010450 (CYP) isoforms in vitro: Preferential inhibition of CYP2D6","volume":"27","author":"Shin J.\u2010G.","year":"1999","journal-title":"Drug Metabolism and Disposition"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1014272"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1301366"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000025"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1049355"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01474.x"},{"key":"e_1_2_9_26_1","first-page":"386","article-title":"Concentration determination of clozapine in human plasma by HPLC","volume":"27","author":"Wu N.","year":"2008","journal-title":"Herald of Medicine"},{"key":"e_1_2_9_27_1","first-page":"283","article-title":"Simultaneous determination of venlafaxine and O\u2010desmethylvenlafaxine in human serum by HPLC\u2010MS\/MS","volume":"35","author":"Xie H.","year":"2019","journal-title":"Chinese Journal of Clinical Pharmacology"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12609"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.2733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.2733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hup.2733","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.2733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:35:49Z","timestamp":1694050549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.2733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,2]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/hup.2733"],"URL":"https:\/\/doi.org\/10.1002\/hup.2733","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,2]]},"assertion":[{"value":"2019-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2733"}}