{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:21:35Z","timestamp":1778538095499,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence, background factors, and progression of and recovery from clozapine\u2010induced agranulocytosis in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on treatment\u2010resistant schizophrenia patients registered with the Clozaril Patient Monitoring Service (CPMS) between July 29, 2009 and January 20, 2016 were extracted. Patients with a neutrophil count &lt;500\/mm<jats:sup>3<\/jats:sup> were defined as having agranulocytosis, and those with a leukocyte count &lt;3,000\/mm<jats:sup>3<\/jats:sup> or a neutrophil count &lt;1,500\/mm<jats:sup>3<\/jats:sup> but not meeting the criteria for agranulocytosis were defined as having leukopenia\/neutropenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 3,746 patients, agranulocytosis and leukopenia\/neutropenia were observed in 38 (1.0%) and 182 (4.9%) patients, respectively. Age was significantly higher in the agranulocytosis group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Decreased leukocyte counts 1 week prior to discontinuation were observed only in the agranulocytosis group. The median number of days to recovery from agranulocytosis and leukopenia\/neutropenia was 10 and 4, respectively, with more variation in the latter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although some patients with leukopenia\/neutropenia might carry less pathologic significance, the results of this study reconfirmed the importance of regular blood monitoring for preventing agranulocytosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2739","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T12:12:48Z","timestamp":1589803968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clozapine\u2010induced agranulocytosis in Japan: Changes in leukocyte\/neutrophil counts before and after discontinuation of clozapine"],"prefix":"10.1002","volume":"35","author":[{"given":"Kentaro","family":"Matsui","sequence":"first","affiliation":[{"name":"Department 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