{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:16Z","timestamp":1788566416790,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess driving performance and neurocognitive skills of long\u2010term users of sedating antidepressants, in comparison to healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight long\u2010term (&gt;6 months) users of amitriptyline (<jats:italic>n<\/jats:italic>= 13) and mirtazapine (<jats:italic>n<\/jats:italic>= 25) were compared to 65 healthy controls. Driving performance was assessed using a 1\u2010h standardised highway driving test in actual traffic, with road\u2010tracking error (standard deviation of lateral position [SDLP]) being the primary measure. Secondary measures included neurocognitive tasks related to driving. Performance differences between groups were compared to those of blood alcohol concentrations of 0.5 mg\/ml to determine clinical relevance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, mean increase in SDLP of all antidepressant users was not significant, nor clinically relevant (+0.75 cm, 95% CI: \u22120.83 cm; +2.33 cm). However, users treated less than 3 years (<jats:italic>n<\/jats:italic>= 20) did show a significant and clinically relevant increase in SDLP (+2.05 cm). No significant effects were observed on neurocognitive tasks for any user group, although large individual differences were present. Most results from neurocognitive tests were inconclusive, while a few parameters confirmed non\u2010inferiority for users treated longer than 3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The impairing effects of antidepressant treatment on driving performance and neurocognition mitigate over time following long\u2010term use of 3 years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2762","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T15:56:18Z","timestamp":1601567778000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Driving performance and neurocognitive skills of long\u2010term users of sedating antidepressants"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4523-4519","authenticated-orcid":false,"given":"Nick N.J.J.M.","family":"van der Sluiszen","sequence":"first","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology Faculty of Psychology and Neuroscience Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-1184","authenticated-orcid":false,"given":"Annemiek","family":"Vermeeren","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Psychopharmacology Faculty of Psychology and Neuroscience Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5368-9353","authenticated-orcid":false,"given":"Joke H.","family":"van Dijken","sequence":"additional","affiliation":[{"name":"Department of Clinical and Developmental Neuropsychology University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-9151","authenticated-orcid":false,"given":"Aurora","family":"J.A.E. van de Loo","sequence":"additional","affiliation":[{"name":"Division Pharmacology Utrecht University Utrecht The Netherlands"},{"name":"Institute for Risk Assessment Sciences Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1604-5321","authenticated-orcid":false,"given":"Janet L.","family":"Veldstra","sequence":"additional","affiliation":[{"name":"Department of Clinical and Developmental Neuropsychology University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0262-4573","authenticated-orcid":false,"given":"Dick","family":"de Waard","sequence":"additional","affiliation":[{"name":"Department of Clinical and Developmental Neuropsychology University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-2096","authenticated-orcid":false,"given":"Joris","family":"C. 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