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We sought to determine which type of amnesia these drugs best model by comparing the effects of diazepam with those reported in amnesiacs regarding working memory capacity (WMC), susceptibility to retroactive interference (RI), and accelerated forgetting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this double\u2010blind, parallel\u2010group design study, 30 undergraduates were randomly allocated to acute oral treatments with 15\u00a0mg diazepam or placebo. WMC and story recall were assessed pre\u2010 and post\u2010treatment. Story presentation was succeeded by 10\u00a0min of RI (spotting differences in pictures) or minimal RI (doing nothing in a darkened room). Delayed story recall was assessed under diazepam and 7 days later in a drug\u2010free session to assess accelerated forgetting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recall of stories encoded under diazepam, whether reactivated or not, was severely impaired (anterograde amnesia). However, diazepam did not impair WMC, increase susceptibility to RI, or accelerate forgetting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diazepam's amnestic effects mirror those in patients with probable severe medial temporal damage, mostly restricted to initial consolidation and differ from other OAA (Korsakoff syndrome, frontal, transient epileptic, posttraumatic amnesia, and most progressive amnesias) in terms of WMC, susceptibility to RI and accelerated forgetting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2774","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T17:24:16Z","timestamp":1609003456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A reappraisal of acute doses of benzodiazepines as a model of anterograde amnesia"],"prefix":"10.1002","volume":"36","author":[{"given":"Isis Ang\u00e9lica","family":"Segura","sequence":"first","affiliation":[{"name":"Departamento de Psicobiologia Universidade Federal de S\u00e3o Paulo\u2010 Escola Paulista de Medicina  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"McGhee","sequence":"additional","affiliation":[{"name":"Department of Psychology Human Cognitive Neuroscience University of Edinburgh  Edinburgh UK"},{"name":"Laboratory of Experimental Psychology Suor Orsola Benincasa University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Della Sala","sequence":"additional","affiliation":[{"name":"Department of Psychology Human Cognitive Neuroscience University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Cowan","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Missouri\u2010Columbia  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5208-8003","authenticated-orcid":false,"given":"Sabine","family":"Pomp\u00e9ia","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiologia Universidade Federal de S\u00e3o Paulo\u2010 Escola Paulista de Medicina  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X99002034"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000091"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2014.04.013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.11.1576"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/073428299901700405"},{"key":"e_1_2_11_7_1","volume-title":"Human memory: Theory and practice","author":"Baddeley A. 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