{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:14:13Z","timestamp":1793229253702,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the long\u2010term safety of switching to brexpiprazole from aripiprazole or non\u2010aripiprazole dopamine antagonists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Post\u2010hoc analysis of 56\u2010week study of Japanese outpatients with schizophrenia switched to brexpiprazole 2\u00a0mg\/day over 4\u2010week switching period with further titration (1\u20134\u00a0mg\/day) allowed during the 52\u2010week, open\u2010label period. Major assessment items: total\/low\u2010density lipoprotein (LDL)\u2010\/high\u2010density lipoprotein (HDL)\u2010cholesterol, triglycerides, blood glucose, body weight and prolactin. Secondary evaluations were related to efficacy, treatment emergent adverse events (TEAEs), extrapyramidal symptoms, and corrected QT interval (QTc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>84\/186 (45.2%) patients (aripiprazole, 32.9%; non\u2010aripiprazole, 54.8%) discontinued treatment over 56 weeks mainly because of consent withdrawal\/adverse events. From baseline to Week 56, both groups showed minimal mean changes in total\/LDL\u2010\/HDL\u2010cholesterol, triglycerides, and glucose levels and a slight increase in mean (SD) body weight (aripiprazole, 1.1 [4.4] kg; non\u2010aripiprazole, 0.4 [4.6] kg). Mean prolactin levels increased slightly in the aripiprazole group, but decreased in the non\u2010aripiprazole group. Symptom severity scores decreased similarly in both groups. TEAEs occurred in 161\/186 (86.6%) patients (aripiprazole, 84.1% [serious, 9.8%]; non\u2010aripiprazole, 88.5% [serious, 14.4%]). Few changes occurred in extrapyramidal symptom scales or QTc interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Switching to brexpiprazole is associated with a low long\u2010term risk for metabolic abnormalities (including weight gain), hyperprolactinemia, extrapyramidal symptoms and QTc changes and minimal changes in psychiatric symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2777","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T13:57:54Z","timestamp":1611669474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Safety of switching to brexpiprazole in Japanese patients with schizophrenia: A post\u2010hoc analysis of a long\u2010term open\u2010label study"],"prefix":"10.1002","volume":"36","author":[{"given":"Jun","family":"Ishigooka","sequence":"first","affiliation":[{"name":"Institute of CNS Pharmacology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-4588","authenticated-orcid":false,"given":"Ken","family":"Inada","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9947-393X","authenticated-orcid":false,"given":"Kazunari","family":"Niidome","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Otsuka Pharmaceutical Co., Ltd.  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