{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:10:01Z","timestamp":1778350201976,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["961002"],"award-info":[{"award-number":["961002"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obsessive\u2010compulsive disorder (OCD) is a common disabling disorder. Crocin, the active component of the saffron plant (Crocus Sativus L.) has various pharmacological activities. The present study compared the efficacy and safety of crocin and fluoxetine in treatment of mild to moderate OCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods &amp; Materials<\/jats:title><jats:p>Fifty patients with OCD, aged 18 to 60 years, were randomized to receive either crocin (15\u00a0mg) or fluoxetine (20\u00a0mg) capsules for 8 weeks. Eligible participants received one capsule\/day in the first month, which followed by two capsules daily in the second month. The patients were evaluated using Yale\u2010Brown Obsessive\u2010compulsive scale (Y\u2010BOCS) and Hamilton Anxiety Rating scale (HARS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean Y\u2010BOCS score in both groups decreased significantly during 2 months (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a00.0001). Also, HARS score in the crocin group was changed from 17.16 to 13.04 whereas, in the fluoxetine group was decreased from 18.28 to 12.34. The results indicated no difference between the two groups in Y\u2010BOCS and HARS score changes after 2\u2010month trial (<jats:italic>p<\/jats:italic>\u2010value &gt;0.5). Also, fewer adverse effects were reported in the crocin group compared to the fluoxetine group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to our study, it seems that crocin is effective in treatment of patients with mild to moderate OCD with possibly fewer adverse effects compared to fluoxetine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2780","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T18:56:53Z","timestamp":1613847413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of crocin versus fluoxetine in treatment of mild to moderate obsessive\u2010compulsive disorder: A double blind randomized clinical trial"],"prefix":"10.1002","volume":"36","author":[{"given":"Fatemeh","family":"Kazemi","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology School of Pharmacy Mashhad University of Medical 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