{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:44Z","timestamp":1753869284151,"version":"3.41.2"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA042146","R01DA031160"],"award-info":[{"award-number":["R01DA042146","R01DA031160"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine prevalence of past\u2010month prescription drug misuse (PDM) and alcohol co\u2010ingestion and its correlates in adults age 50 or older.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were from the 2015\u20132018 US National Survey on Drug Use and Health (<jats:italic>n<\/jats:italic>\u00a0=\u00a035,190). PDM\u2010alcohol co\u2010ingestion was defined as prescription opioid, tranquilizer\/sedative, or stimulant misuse while \u201cdrinking alcohol or within a couple of hours of drinking.\u201d Co\u2010ingestion prevalence was estimated, and logistic and negative binomial regressions examined the sociodemographic, physical health, mental health, substance use, and substance use disorder (SUD) correlates of co\u2010ingestion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 344,000 adults aged 50 years or older (0.3%) engaged in past\u2010month PDM\u2010alcohol co\u2010ingestion, or 27.4% of those with past\u2010month PDM. Past\u2010month co\u2010ingestion was linked to greater past\u2010month alcohol use frequency and elevated adjusted odds ratios (aORs) for all examined substance use outcomes (e.g., non\u2010PDM SUD aOR\u00a0=\u00a021.8; 49.7% prevalence rate). The aOR for suicidal ideation was 506% higher in those with co\u2010ingestion than those without past\u2010year PDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>US adults aged 50 years or older with past\u2010month PDM\u2010alcohol co\u2010ingestion are at high risk for SUD and concerning mental health symptoms. Screening for mental health and substance use treatment is warranted among aging adults with signs of PDM, especially involving co\u2010ingestion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2803","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T16:31:00Z","timestamp":1625761860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Co\u2010ingestion of prescription drugs and alcohol in US adults aged 50 years or older"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-0496","authenticated-orcid":false,"given":"Ty S.","family":"Schepis","sequence":"first","affiliation":[{"name":"Department of Psychology Texas State University  San Marcos Texas USA"},{"name":"Center for the Study of Drugs Alcohol, Smoking and Health Department of Health Behavior and Biological Sciences School of Nursing University of Michigan  Ann Arbor Michigan 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