{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:07:45Z","timestamp":1768464465105,"version":"3.49.0"},"reference-count":75,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the literature on valproate\u2010associated hair abnormalities and the available treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed and Google Scholar with keywords including \u201cvalproate\u201d, \u201cvalproic acid\u201d, \u201chair\u201d, \u201calopecia\u201d, and \u201ceffluvium,\u201d supplemented with hand search from cross\u2010references. We included all types of studies including case reports in this review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pathophysiology of hair loss includes telogen effluvium, biotin, mineral deficiency, and possibly hyperandrogenism. Diagnosis is based on history of hair\u00a0loss or abnormalities following valproate treatment, and is confirmed by use of simple clinical tests such as pull test and modified wash test. Treatment involves\u00a0reassurance and advice on hair care, and if possible drug discontinuation\u00a0or\u00a0dose reduction. Medications such as biotin and other vitamins with minerals\u00a0supplementation is effective for most individuals with hair loss. Other treatment options are agomelatine, topical valproate or minoxidil, though these lack evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hair abnormalities with valproate are common, benign adverse effects, and management includes general measures and specific treatment options.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2814","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T07:10:27Z","timestamp":1631862627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Valproate\u2010associated hair abnormalities: Pathophysiology and management strategies"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-1432","authenticated-orcid":false,"given":"Samir Kumar","family":"Praharaj","sequence":"first","affiliation":[{"name":"Department of Psychiatry Kasturba Medical College Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindra N.","family":"Munoli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kasturba Medical College Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suma T.","family":"Udupa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kasturba Medical College Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivapriya","family":"Vaidyanathan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kasturba Medical College Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2017.04.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010018\u20100278\u20106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5070\/D38S34P6B7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.07.008"},{"issue":"2","key":"e_1_2_10_6_1","first-page":"91","article-title":"Effects of tocotrienol supplementation on hair growth in human volunteers","volume":"21","author":"Beoy L. 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