{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:14:56Z","timestamp":1764828896457,"version":"3.41.2"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hypothermia is a potentially lethal adverse reaction to typical and atypical antipsychotic drugs (APD). Among predisposing factors are advanced age and comorbid somatic diseases. The aim of this study was to assess the incidence of hypothermia and quantify risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Charts of <jats:italic>N<\/jats:italic>\u00a0=\u00a03002 psychogeriatric inpatients were screened for incidence of hypothermia (body core temperature &lt;35.0\u00b0C). The frequency of hypothermia was compared between patients treated with versus without APD and, within the sample of APD\u2010treated patients, for (1) specific APD, (2) sex, (3) main diagnosis, and (4) age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>N<\/jats:italic>\u00a0=\u00a054 cases (2.6%) of hypothermia occurred in APD\u2010treated patients and 12 cases (1.3%) in non\u2010APD\u2010treated patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.024). In APD\u2010treated patients, only male sex (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.038) and pipamperone were associated with a higher incidence of hypothermia (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0017). Whereas the main diagnosis delirium showed a trend to significance, age did not correlate with hypothermia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Medication with pipamperone was associated with an increased risk of hypothermia. The advanced age of our sample might as well explain the high incidence of hypothermia within our sample and the failure to detect high age as a risk factor due to a ceiling effect.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2816","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T07:33:02Z","timestamp":1631863982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics of antipsychotic drug\u2010induced hypothermia in psychogeriatric inpatients"],"prefix":"10.1002","volume":"37","author":[{"given":"Daniel","family":"Kamp","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrella","family":"Paschali","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative, and Pain Medicine Brigham and Women's Hospital\/Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabelle","family":"Bouanane","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Christl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tillmann","family":"Supprian","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Meisenzahl\u2010Lechner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Kojda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology Medical Faculty Heinrich\u2010Heine\u2010University  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lange\u2010Asschenfeldt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Oberberg Clinic Group Clinics for Psychiatry, Psychosomatics and Psychotherapy Oberberg Kliniken  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"189","article-title":"Fatal hyperpyrexia during chlorpromazine therapy","volume":"17","author":"Ayd F. 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