{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:26:07Z","timestamp":1783992367999,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Long\u2010acting injectable (LAI) antipsychotics were developed to improve adherence to schizophrenia treatment. Paliperidone palmitate (PP) has two LAI forms: Monthly (PP1M) and three\u2010monthly (PP3M). PP3M shows less difference in Peak\u2010to\u2010Trough drug concentration levels. This could be related to a lower incidence of hyperprolactinemia, which may negatively affect adherence. We aimed to compare prolactin levels and investigate relationships between prolactin levels, symptomatology and sexual function in patients with schizophrenia after switching from PP1M to PP3M.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five patients were enrolled. The sociodemographic data form, the Positive and Negative Syndromes Scale (PANSS) and the Arizona Sexual Experience Scale (ASEX) were used. Morning blood samples were drawn to determine prolactin levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prolactin level (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), the total score and arousal sub\u2010score of ASEX (respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.015, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.020) and the total score and positive scale of PANSS (respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) were decreased on the 90th day (\u00b115 days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After switching to PP3M, the decreases in prolactin levels and potentially related sexual side effects was statistically significant. There may be a difference between two formulations of the same drug in terms of side effects, and there is a need for prospective follow\u2010up studies with larger samples.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2827","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T16:58:05Z","timestamp":1637168285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prospective analysis of serum prolactin levels, clinical symptomatology and sexual functions in patients with schizophrenia switched to paliperidone palmitate 3\u2010monthly from paliperidone palmitate 1\u2010monthly: Preliminary findings of the first 3 months"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2118-4358","authenticated-orcid":false,"given":"Ersin Hatice","family":"Karslio\u011flu","sequence":"first","affiliation":[{"name":"Department of Psychiatry Ankara Oncology Research and Training Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Kolcu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ankara Oncology Research and Training Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisa \u0130rem","family":"Karslio\u011flu","sequence":"additional","affiliation":[{"name":"Ankara University Medical Faculty  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"\u00c7ayk\u00f6yl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ankara Oncology Research and Training Hospital Y\u0131ld\u0131r\u0131m Beyaz\u0131t University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.02.019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2012.03.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2010.010025"},{"key":"e_1_2_9_6_1","author":"\u00c7akmak S.","year":"2010","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.656590"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881112442016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-12-26"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-018-0899-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145704005012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R123"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"51","article-title":"[Adaptation and reliability of the structured clinical interview for DSM\u20105\u2010disorders\u2014clinician version (SCID\u20105\/CV) to the Turkish language]","volume":"30","author":"Elbir M.","year":"2019","journal-title":"Turk Psikiyatri Dergisi = Turkish Journal of Psychiatry"},{"issue":"16","key":"e_1_2_9_14_1","first-page":"18","article-title":"Comparison of the effects of different routes of antipsychotic administration on pharmacokinetics and pharmacodynamics","volume":"64","author":"Ereshefsky L.","year":"2003","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.04.033"},{"key":"e_1_2_9_16_1","author":"First, M. 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