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After smoking, participants freely gazed back and forth at a series of two side\u2010by\u2010side pictures pairs presented for 3000\u00a0ms (one negative, while the other was either positive or neutral) while eye gaze was tracked.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The effects of THC relative to placebo varied across time such that THC increased NAB during the early temporal component of threatening picture viewing, 333\u2013858\u00a0ms after dual\u2010picture onset, regardless of alternative picture valance. However, contrary to the attentional bias\u2010causes affect hypothesis, during the early viewing phase THC\u2010enhanced positive affect (PA)\u00a0correlated positively with THC\u2010induced NAB. In contrast, during the late phase (891\u20133000\u00a0ms) THC\u2010enhanced PA did not correlate significantly with NAB, though THC\u2010induced negative affect (NA) change did correlate positively with THC\u2010induced change in NAB in the positive alternative condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We replicated findings of others showing that THC can enhance NAB during the early stages of threatening picture viewing. We extended previous results by demonstrating the THC\u2010induced NAB is associated with increased PA during initial threat viewing, but with increased NA during later processing if positive alternatives are present.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2844","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T04:55:01Z","timestamp":1650603301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Cannabis\u2010Delivered THC on mood and negative attentional bias in the context of positive vs. neutral Alternatives\u2014a pilot study"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1017-8577","authenticated-orcid":false,"given":"Matthew P.","family":"Gunn","sequence":"first","affiliation":[{"name":"Department of Psychology Southern Illinois University  Carbondale Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norka E.","family":"Rabinovich","sequence":"additional","affiliation":[{"name":"Department of Psychology Southern Illinois University  Carbondale Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris M.","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Psychology Southern Illinois University  Carbondale Illinois USA"},{"name":"Department of Psychology West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Lindt","sequence":"additional","affiliation":[{"name":"Department of Psychology Southern Illinois University  Carbondale Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7525-7239","authenticated-orcid":false,"given":"David G.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Psychology Southern Illinois University  Carbondale Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2010.06.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0018516"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"560","article-title":"Marijuana smoking: Effects of varying puff volume and breathhold duration","volume":"272","author":"Azorlosa J. 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