{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:17:00Z","timestamp":1788999420944,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe \u00dcniversitesi","doi-asserted-by":"publisher","award":["10702"],"award-info":[{"award-number":["10702"]}],"id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate brain connectivity by diffusion tensor imaging (DTI) in schizophrenia patients with clozapine\u2010induced obsessive compulsive symptoms (OCS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen schizophrenia patients, nine of which had clozapine\u2010induced OCS (Clz\u2010OCS (+)), 9 without OCS (Clz\u2010OCS (\u2212)) and 9 healthy controls were included. Psychopathology was evaluated with Positive and Negative Syndrome Scale and Yale\u2010Brown Obsession and Compulsion Scale in the patient groups. All groups were assesed with neurocognitive tests and DTI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tract\u2010Based Spatial Statistics based comparison of DTI revealed lower fractional anisotropy in the genu of corpus callosum (CC), right cingulum, left frontal white matter (WM) in the Clz\u2010OCS (+) group, compared to controls. Fractional anisotropy was found to be lower in the bilateral occipital WM and higher in the bilateral medial temporal regions, anterior limb of internal capsule, cingulum, frontoparietal peripheral WM, right external capsule and genu of CC in Clz\u2010OCS (+) patients compared to Clz\u2010OCS (\u2212).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>WM integrity in several pathways such as cortico\u2010striato\u2010thalamo\u2010cortical circuitry and orbito\u2010frontal tracts seems to be affected differently in patients with Clz\u2010OCS (+). Different neuroplastic effects of clozapine leading to occurrence of OCS in a subgroup of patients is possible, and needs further evaluation by longitudinal follow\u2010up studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2857","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T08:13:36Z","timestamp":1668586416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A diffusion tensor imaging study in schizophrenia patients with clozapine induced obsessive compulsive symptoms"],"prefix":"10.1002","volume":"38","author":[{"given":"\u015eule","family":"B\u0131\u00e7akc\u0131 Ay","sequence":"first","affiliation":[{"name":"Department of Psychiatry Baskent University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kader K.","family":"O\u011fuz","sequence":"additional","affiliation":[{"name":"Department of Radiology Hacettepe University Faculty of Medicine  Ankara Turkey"},{"name":"National MR Research Center (UMRAM) Bilkent University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2447-7263","authenticated-orcid":false,"given":"El\u00e7in","family":"\u00d6z\u00e7elik Ero\u011flu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu Ceylan","family":"Has","sequence":"additional","affiliation":[{"name":"National MR Research Center (UMRAM) Bilkent University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayg\u00fcn","family":"Ertu\u011frul","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2013.09.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2012.09.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.07.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053\u2010199803000\u201000003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1348\/026151008X314919"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.15.3.359"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010013\u20103137\u20102"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.02.313"},{"key":"e_1_2_9_10_1","volume-title":"DSM\u2010IV Eksen 1 bozukluklar\u0131 i\u00e7in yap\u0131land\u0131r\u0131lm\u0131\u015f klinik g\u00f6r\u00fc\u015fme (SCID), Klinik versiyon","author":"Corapcioglu A.","year":"1999"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.05.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13040574"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.11.021"},{"key":"e_1_2_9_14_1","volume-title":"Adaptation of phonemic and semantic verbal fluency tests for Turkish language","author":"Erden Aki O.","year":"2013"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101819.2005.01362.x"},{"key":"e_1_2_9_16_1","volume-title":"User's guide for the structured clinical interview for DSM\u2010IV Axis I disorders SCID\u2010I: Clinician version","author":"First M. B.","year":"1997"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.06.011"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010014\u20100510\u20108"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.22"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.11.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506280444000076"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20111601"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.09.031"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113665"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.23008"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.053"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.1.91"},{"key":"e_1_2_9_29_1","first-page":"46","article-title":"Wechsler bellek \u00d6l\u00e7e\u011fi Geli\u015ftirilmi\u015f Formunun test\u2010tekrar test g\u00fcvenirli\u011fi","volume":"11","author":"Karaka\u015f S.","year":"1996","journal-title":"T\u00fcrk Psikoloji Dergisi"},{"key":"e_1_2_9_30_1","volume-title":"Summary book","author":"Karamustafaoglu O.","year":"1993"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/13.2.261"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2017.04.004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1607\u2010551X(09)70121\u20104"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505876"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.180087"},{"key":"e_1_2_9_36_1","first-page":"23","article-title":"Pozitif ve Negatif Sendrom \u00d6l\u00e7e\u011finin (PANSS) T\u00fcrk\u00e7e uyarlamas\u0131n\u0131n ge\u00e7erlilik g\u00fcvenilirli\u011fi","volume":"14","author":"Kostakoglu E.","year":"1999","journal-title":"T\u00fcrk Psikoloji Dergisi"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.1.16"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2009.6.4.286"},{"key":"e_1_2_9_39_1","volume-title":"Neuropsychological assessment","author":"Lezak M. D.","year":"1995"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000211801.66569.80"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.14.4.449"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010050911\u2010161504"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010018\u20100965\u20104"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108089582"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2014.06.001"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.05.009"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2013.01.016"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102004\u2010815525"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1707050114"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.94"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31242"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.05.029"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m07164"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000419"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.140021"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015912799362724"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00099"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713001803"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702614534210"},{"key":"e_1_2_9_61_1","volume-title":"Compendium of neuropsychological tests: Administration, norms, and commentary","author":"Spreen O.","year":"1998"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127\u2010012\u20100507\u20108"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.10.033"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2011.01638.x"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.1995.tb09801.x"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2021.113772"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.693109"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2017.09.014"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbz073"},{"key":"e_1_2_9_70_1","volume-title":"The wechsler memory scale\u2010revised","author":"Wechsler D.","year":"1987"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.03.007"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.2007.01046.x"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.06.032"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2020.102467"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.08.027"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.2857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hup.2857","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.2857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T11:22:00Z","timestamp":1695727320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.2857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,16]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/hup.2857"],"URL":"https:\/\/doi.org\/10.1002\/hup.2857","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,16]]},"assertion":[{"value":"2022-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2857"}}