{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:48Z","timestamp":1753869288439,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the impact of solriamfetol, a dopamine and norepinephrine reuptake inhibitor, on on\u2010the\u2010road driving performance in participants with narcolepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomised, double\u2010blind, placebo\u2010controlled, crossover study, driving performance during a 1\u00a0h on\u2010road driving test was assessed at 2 and 6\u00a0h post\u2010dose following 7\u00a0days of treatment with solriamfetol (150\u00a0mg\/day for 3\u00a0days, followed by 300\u00a0mg\/day for 4\u00a0days) or placebo. The primary endpoint was standard deviation of lateral position (SDLP) at 2\u00a0h post\u2010dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 24 participants (54% male; mean age, 40\u00a0years); 22 had evaluable SDLP data. At 2\u00a0h post\u2010dose, median SDLP was significantly lower (improved) with solriamfetol compared with placebo (19.08 vs. 20.46\u00a0cm [median difference, \u22121.9\u00a0cm], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). Four participants on solriamfetol and 7 on placebo had incomplete driving tests. At 6\u00a0h post\u2010dose, median SDLP was not statistically significantly different with solriamfetol compared with placebo (19.59 vs. 19.78\u00a0cm [median difference, \u22121.1\u00a0cm], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.125). Three participants on solriamfetol and 10 on placebo had incomplete driving tests. Common adverse events (\u22655%) included headache, decreased appetite, and somnolence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Solriamfetol 300\u00a0mg\/day improved on\u2010the\u2010road driving performance, at 2\u00a0h post\u2010administration in participants with narcolepsy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2858","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T13:33:01Z","timestamp":1669296781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of solriamfetol on on\u2010the\u2010road driving in participants with narcolepsy: A randomised crossover trial"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1767-7742","authenticated-orcid":false,"given":"Frederick","family":"Vinckenbosch","sequence":"first","affiliation":[{"name":"Faculty of Psychology and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert Jan","family":"Lammers","sequence":"additional","affiliation":[{"name":"Sleep\u2013Wake Centre SEIN  Leiden The Netherlands"},{"name":"Department of Neurology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiaan","family":"Overeem","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center Kempenhaeghe  Heeze The Netherlands"},{"name":"Department of Electrical Engineering Biomedical Diagnostics Group Eindhoven University of Technology  Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Wang","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence P.","family":"Carter","sequence":"additional","affiliation":[{"name":"Alector Inc  South San Francisco California USA"},{"name":"University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kefei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes G.","family":"Ramaekers","sequence":"additional","affiliation":[{"name":"Faculty of Psychology and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemiek","family":"Vermeeren","sequence":"additional","affiliation":[{"name":"Faculty of Psychology and Neuroscience Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/nss.s245020"},{"key":"e_1_2_9_3_1","unstructured":"American Academy of Sleep Medicine. 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