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Bazett\u2010corrected QT (QTc) was manually calculated from ECGs measured at baseline (before aripiprazole) and week 12, by two doctors blind to the diagnosis and atypical antipsychotic. The change in QTc (\u2206QTc: baseline QTc\u2013week 12 QTc) and the number of participants in normal, borderline, prolonged, and pathological groups after 12\u00a0weeks were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five participants, mean age of 39.3 (SD 8.2) years, were analyzed. The \u2206QTc after 12\u00a0weeks was 5.9\u00a0ms (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.143) for the whole sample; 16.4\u00a0ms (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.762), 3.7\u00a0ms (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.480) and 0.5\u00a0ms (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.449), for the clozapine, risperidone and olanzapine group, respectively. There was no significant statistical difference comparing the change in QTc overall, and between atypical antipsychotic groups, when evaluating from baseline to endpoint. However, stratifying the sample based on sex\u2010dependent QTc cut\u2010offs showed a 45% decrease in abnormal QTc readings (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.049) after aripiprazole initiation; 20 subjects had abnormal QTc at baseline, while only 11 subjects had abnormal QTc at 12\u00a0weeks. 25.5% of participants showed a reduction in at least one QTc severity group, while 65.5% had no change and 9.0% worsened in QTc group, after 12\u00a0weeks of adjunct aripiprazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010dose adjunctive aripiprazole did not prolong QTc in patients stabilized on either olanzapine, risperidone, or clozapine. More controlled studies evaluating the QTc effect of adjunctive aripiprazole should be done to confirm and support these findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2863","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T09:45:00Z","timestamp":1677059100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of adjunctive aripiprazole on QT interval: A 12\u2010week open label study in patients on olanzapine, clozapine or risperidone"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-6946","authenticated-orcid":false,"given":"Thanita","family":"Pilunthanakul","sequence":"first","affiliation":[{"name":"Department of Emergency and Crisis Care Institute of Mental Health  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mable Quek 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