{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:15:55Z","timestamp":1791126955543,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T00:00:00Z","timestamp":1677369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this systematic review is to assess the efficacy and safety of hydroxyzine for insomnia in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search of PubMed, Embase, and CENTRAL databases was conducted to identify relevant published studies through October 2022 using the search terms: hydroxyzine and sleep, insomnia, sleep disorder or sleep initiation and maintenance disorders. Studies identified for review included prospective, interventional designs or cohort trials that reported impact of hydroxyzine on sleep in adults. Animal studies, case reports, non\u2010English articles, letters to the editor, case studies, and conference abstracts were excluded. Data were extracted using a standardized systematic process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five articles were identified for inclusion, including 1 open\u2010label and 4 randomized controlled trials, evaluating a total of 207 patients receiving hydroxyzine 25\u00a0mg, 50\u00a0mg, or 100\u00a0mg at bedtime. Mixed efficacy was demonstrated in the sleep measures of sleep onset, sleep maintenance, and sleep quality. The most common adverse drug effect was dry mouth, although 4 of the 5 studies did not report safety outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The studies in this review suggest hydroxyzine could be considered as a short\u2010term treatment option for adults with insomnia for\u00a0whom previous therapy was ineffective, not tolerated, or contraindicated. Additional long\u2010term studies with an active comparator are needed to further establish its role in insomnia treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2864","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T04:29:03Z","timestamp":1677472143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy and safety of hydroxyzine for sleep in adults: Systematic review"],"prefix":"10.1002","volume":"38","author":[{"given":"Courtney R.","family":"Burgazli","sequence":"first","affiliation":[{"name":"Geriatric Research Education and Clinical Center Durham VA Health Care System  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna B.","family":"Rana","sequence":"additional","affiliation":[{"name":"Geriatric Research Education and Clinical Center Durham VA Health Care System  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6839-5948","authenticated-orcid":false,"given":"Jamie N.","family":"Brown","sequence":"additional","affiliation":[{"name":"Pharmacy Service Durham VA Health Care System  Durham North Carolina USA"},{"name":"Department of Pharmacy Practice Campbell University College of Pharmacy and Health Sciences  Buies Creek North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Frank","family":"Tillman","sequence":"additional","affiliation":[{"name":"Pharmacy Service Durham VA Health Care System  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362243"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.470070104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014381"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20101781(89)90047\u20104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1021137118956"},{"key":"e_1_2_9_9_1","volume-title":"Lexi\u2010drugs","author":"Hydroxyzine","year":"2021"},{"key":"e_1_2_9_10_1","unstructured":"Hydroxyzine [package insert]. 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