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Even small structural changes affect their interactions with key proteins. This article reviews existing knowledge of the mechanisms of action of cathinones at the molecular level, and key findings from research on their structure\u2010activity relationship. The cathinones are also classified according to their chemical structure and neuropharmacological profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Synthetic cathinones represent one of the most numerous and widespread groups among new psychoactive substances. Initially developed for therapeutic purposes, they quickly started to be used recreationally. With a rapidly increasing number of new agents entering the market, structure\u2010activity relationship studies are valuable for assessing and predicting the addictive potential and toxicity of new and potential future substances. The neuropharmacological properties of synthetic cathinones are still not fully understood. A full elucidation of the role of some key proteins, including organic cation transporters, requires detailed studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2866","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T09:59:34Z","timestamp":1677837574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A narrative review of the neuropharmacology of synthetic cathinones\u2014Popular alternatives to classical drugs of abuse"],"prefix":"10.1002","volume":"38","author":[{"given":"Patryk","family":"Kuropka","sequence":"first","affiliation":[{"name":"Institute of Toxicology Research  Borowa Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Zawadzki","sequence":"additional","affiliation":[{"name":"Institute of Toxicology Research  Borowa Poland"},{"name":"Department of Forensic Medicine Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Szpot","sequence":"additional","affiliation":[{"name":"Institute of Toxicology Research  Borowa Poland"},{"name":"Department of Forensic Medicine Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640\u2010019\u201000020\u20102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376\u20108716(98)00068\u20104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312995"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2610"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.204"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010018\u20104962\u20100"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010018\u20105063\u20109"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13030"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12061"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2582"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.09.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0091\u20103057(97)00323\u20107"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.01.020"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108475"},{"key":"e_1_2_9_17_1","unstructured":"EMCDDA. 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