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Selective serotonin reuptake inhibitor (SSRI) drugs were hypothesized to improve the prognosis of COVID\u201019 pneumonia, a typical acute inflammation, in terms of decreased mortality rate and pro\u2010inflammatory cytokine serum levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of COVID\u201019 pneumonia inpatients at Careggi University Hospital (Florence) were analyzed for prognosis and Interleukin 6 (IL\u20106) after admission for over a period of 22\u00a0months. Medical records of patients treated at admission and not discontinued until discharge with an SSRI or with vortioxetine were identified. Two groups, one treated with antidepressants, the other not treated, were evaluated according to the mentioned parameters. Multiple linear regression and logistic regression were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The entire sample composed of 1236 records (recovered patients 77.1%, deceased patients 22.9%). The treated group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0107) had a better prognosis than the untreated group in spite of age and comorbidity both being greater than in the untreated group. Correspondingly, IL\u20106 levels in the treated group were significantly lower (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) than the levels in the untreated group, in every comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Outcomes of this study support the hypothesis of the favorable influence of some antidepressants on the prognosis of COVID\u201019, possibly mediated by IL\u20106 modulation. Reduction in acute inflammation induced by the action of antidepressants was confirmed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2887","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T04:20:46Z","timestamp":1702009246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["SSRIs in the course of COVID\u201019 pneumonia: Evidence of effectiveness of antidepressants on acute inflammation. 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