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A consistent subgroup of patients may not achieve adequate symptom remission with first\u2010line treatments (i.e., cognitive behavioral therapy, selective serotonin reuptake inhibitors [SSRIs]). The most validated option for treatment\u2010resistant cases relies on the augmentative use of antipsychotics to SSRIs, preferably of the \u2018second generation\u2019. Indeed, dopamine appears to be crucially involved in OCD neuropathology due to its implication in systems relating to goal\u2010directed behaviour and maladaptive habits. Nevertheless, the mechanism of action of antipsychotics in OCD symptom improvement is still unclear. Risperidone, aripiprazole, and haloperidol seem to be the most useful medications, whereas \u2018first generation\u2019 antipsychotics may be indicated in case of comorbidity with tics and\/or Tourette Syndrome. Antipsychotic augmentation may be also related to side\u2010effects, particularly in the long term (e.g., alteration in metabolic profile, sedation, extrapyramidal symptoms). The present mini\u2010review sought to provide the most updated evidence on augmentative antipsychotic use in treatment\u2010resistant patients with OCD, providing a road map for clinicians in daily practice and shedding light on avenues for further research.<\/jats:p>","DOI":"10.1002\/hup.2893","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T11:09:08Z","timestamp":1707563348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The use of antipsychotics in obsessive compulsive disorder"],"prefix":"10.1002","volume":"39","author":[{"given":"Dario","family":"Conti","sequence":"first","affiliation":[{"name":"Department of Mental Health Department of Biomedical and Clinical Sciences Luigi Sacco University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaja","family":"Girone","sequence":"additional","affiliation":[{"name":"Department of 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