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In previous audio\u2010visual multisensory integration (McGurk effect) studies, widening of TBWs has been observed in people with schizophrenia. The present study aimed to determine if dexamphetamine could increase TBWs in unimodal auditory and unimodal visual illusions that may have some validity as experimental models for auditory and visual hallucinations in psychotic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind, placebo\u2010controlled, counter\u2010balanced crossover design with permuted block randomisation for drug order was followed. Dexamphetamine (0.45\u00a0mg\/kg, PO, q.d.) was administered to healthy participants. Phantom word illusion (speech illusion) and visual\u2010induced flash illusion\/VIFI (visual illusion) tests were measured to determine if TBWs were altered as a function of delay between stimuli presentations. Word emotional content for phantom word illusions was also analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dexamphetamine significantly increased the total number of phantom words\/speech illusions (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) for pooled 220\u20131100\u00a0ms ISIs in kernel density estimation and the number of positive valence words heard (beta\u00a0=\u00a02.20, 95% CI [1.86, 2.55], <jats:italic>t<\/jats:italic>\u00a0=\u00a012.46, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) with a large effect size (std. beta\u00a0=\u00a01.05, 95% CI [0.89, 1.22]) relative to placebo without affecting the TBWs. For the VIFI test, kernel density estimation for pooled 0\u2013801\u00a0ms ISIs showed a significant difference (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) in the data distributions of number of target flash (es) perceived by participants after receiving dexamphetamine as compared with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, healthy participants who were administered dexamphetamine (0.45\u00a0mg\/kg, PO, q.d.) experienced increases in auditory and visual illusions in both phantom word illusion and VIFI tests without affecting their TBWs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2896","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T14:00:12Z","timestamp":1707919212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dexamphetamine increased speech and visual unimodal illusions in healthy participants without affecting temporal binding window"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9738-0617","authenticated-orcid":false,"given":"Fui\u2010Ling","family":"Voon","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Biomedical Sciences The University of Western Australia  Nedlands Western Australia Australia"},{"name":"Faculty of Resources Science and Technology Universiti Malaysia Sarawak  Kota Samarahan Sarawak Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean J.","family":"Loffman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Biomedical Sciences The University of Western Australia  Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J. 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