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All adult psychiatric out\u2010patients on clozapine treatment attending follow\u2010up at a regional hospital were recruited for clinical interview and medical record review. The Enhanced Asian Rome III Questionnaire (EAR3Q) was used to define patients with constipation. The Bristol Stool Form Scale (BSFS) was used to assess stool form. The Brief Psychiatric Rating Scale\u2010Anchored (BPRS\u2010A) was used to measure psychiatric symptoms. The Brief Medication Adherence Scale (BMAS) was used to assess treatment adherence. Logistic regression was conducted to identify independent associating factors of constipation in patients on clozapine treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of constipation in patients on clozapine treatment was 26.3%, (95% CI [21.5%, 31.6%]). Independent associating factors included disorder of psychological development (aOR\u00a0=\u00a06.98, 95% CI [1.24, 39.18]), anxiety (very mild: aOR\u00a0=\u00a09.23, 95% CI [2.59, 32.87]; mild: aOR\u00a0=\u00a02.66, 95% CI [1.26, 5.62]), prescription with combination of laxatives (aOR\u00a0=\u00a00.40, 95% CI [0.17, 0.95]), and concomitant use of amisulpride (aOR\u00a0=\u00a02.52, 95% CI [1.09, 5.82]), quetiapine (aOR\u00a0=\u00a05.92, 95% CI [1.11, 31.56]) and metamucil (aOR\u00a0=\u00a09.30, 95% CI [1.53, 56.58]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study examined the prevalence of clozapine\u2010associated constipation in Hong Kong using a validated questionnaire. The identification of independent factors associated with constipation could facilitate better risk stratification and risk modification in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2897","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T05:48:45Z","timestamp":1712900925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The prevalence of constipation in adult psychiatric out\u2010patients on clozapine treatment at a regional public hospital in Hong Kong"],"prefix":"10.1002","volume":"39","author":[{"given":"Eric Wai\u2010Fung","family":"Lam","sequence":"first","affiliation":[{"name":"Department of Psychiatry Pamela Youde Nethersole Eastern Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Pak\u2010In","family":"Ip","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Pamela Youde Nethersole Eastern Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9872936"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.8.1305"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125315591917"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/3315487"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(21)00111\u20104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2010.04273.x"},{"key":"e_1_2_10_8_1","unstructured":"Center for Food Safety Food and Environmental Hygiene Department. 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