{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:43:26Z","timestamp":1772822606708,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100019412","name":"Bursa Uluda\u011f \u00dcniversitesi","doi-asserted-by":"publisher","award":["T\u20102011\/3"],"award-info":[{"award-number":["T\u20102011\/3"]}],"id":[{"id":"10.13039\/100019412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To define the impact of obesity on inflammatory and oxidative disturbances in antipsychotic\u2010treated schizophrenia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Several cytokines, inflammatory, metabolic, and oxidative status markers were evaluated in obese (<jats:italic>n<\/jats:italic>\u00a0=\u00a040) and non\u2010obese (<jats:italic>n<\/jats:italic>\u00a0=\u00a040) antipsychotic\u2010treated patients and compared with age\u2010and BMI\u2010matched controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a080).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Schizophrenia\u00a0patients had higher leptin, TNF\u2010\u03b1, adiponectin, visfatin, resistin, P\u2010selectin, NPY, BDNF, CD40\u2010L, MCP\u20101, and malondialdehyde, and lower IL\u20106, ghrelin, neopterin, and vitamin E levels compared to their respective controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Total oxidant status was higher in non\u2010obese patients compared to controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), total antioxidant capacity was higher in obese compared to non\u2010obese patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), but vitamin A and paraoxonase levels were not different. High sensitive\u2010CRP levels were higher in obsese controls relative to non\u2010obese controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and in obese patients relative to non\u2010obese patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Fasting glucose, insulin, HbA1c, HOMA\u2010IR, uric acid, total cholesterol, and triglyceride concentrations were higher in obese patients compared to non\u2010obese patients. Insulin concentrations and HOMA\u2010IR were also higher in obese controls than in non\u2010obese controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that inflammatory responses and oxidative stress develop independently from obesity in antipsychotic\u2010treated schizophrenia patients. However, schizophrenia\u2010induced obesity causes metabolic disturbances; thereby, obese schizophrenia patients are more liable to cardiovascular events and progress of metabolic syndrome than non\u2010obese patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2913","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T06:35:33Z","timestamp":1731047733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antipsychotic\u2010Treated Schizophrenia Patients Develop Inflammatory and Oxidative Responses Independently From Obesity: However, Metabolic Disturbances Arise From Schizophrenia\u2010Related Obesity"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-7196","authenticated-orcid":false,"given":"Emre","family":"Sarandol","sequence":"first","affiliation":[{"name":"Medical Faculty Departments of Medical Biochemistry Bursa Uludag Universitiy  Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-8254","authenticated-orcid":false,"given":"Asli","family":"Sarandol","sequence":"additional","affiliation":[{"name":"Medical Faculty Departments of Psychiatry Bursa Uludag Universitiy  Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8209-5942","authenticated-orcid":false,"given":"Sener","family":"Mercan","sequence":"additional","affiliation":[{"name":"Medical Faculty Departments of Psychiatry Bursa Uludag Universitiy  Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-8669","authenticated-orcid":false,"given":"Salih Saygin","family":"Eker","sequence":"additional","affiliation":[{"name":"Medical Faculty Departments of Psychiatry Bursa Uludag Universitiy  Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-9682","authenticated-orcid":false,"given":"Esma","family":"Surmen\u2010Gur","sequence":"additional","affiliation":[{"name":"Medical Faculty Departments of Medical Biochemistry Bursa Uludag Universitiy  Bursa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010018\u20100303\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370204700805"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e3283377850"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.04.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11126\u2010018\u20109606\u20103"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/pteridines\u20102020\u20100012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.47626\/2237\u20106089\u20102020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02912908"},{"issue":"6","key":"e_1_2_9_10_1","article-title":"The Human Serum Paraoxonase\/Arylesterase Polymorphism","volume":"35","author":"Eckerson H. 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