{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:48:29Z","timestamp":1789645709397,"version":"4.0.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate agomelatine treatment in elderly patients with major depressive disorder (MDD) who developed hyponatremia while using selective serotonin receptor inhibitors (SSRIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (60\u00a0years or older) with hyponatremia after SSRI treatment for MDD were changed to agomelatine 50\u00a0mg\/day during one month to observe sodium levels during the treatment and change in depressive symptoms. Montgomery\u2010Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression Scale (CGI) of severity were used before and after treatment with agomelatine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of our sample (five patients) was 75.3 (SD\u00a0\u00b1\u00a07.8) years. Sodium levels while using SSRIs were reported with a mean of 122.54 (SD\u00a0\u00b1\u00a010.8) mEq\/L. Mean MADRS and CGI scores on SSRIs before treatment with agomelatine were 27.8 (SD\u00a0\u00b1\u00a03.90) and 5 (SD\u00a0\u00b1\u00a00.71) respectively. After 4\u00a0weeks of treatment with agomelatine 50\u00a0mg\/day, mean scores of sodium were reported at 135.48 (SD\u00a0\u00b1\u00a01.6) mEq\/L, and mean MADRS and CGI scores were 13.6 (SD\u00a0\u00b1\u00a08.35) and 2.4 (SD\u00a0\u00b1\u00a01.5). The difference in means of the MADRS scale before and after treatment with agomelatine was found to be statistically significant (27.8 [3.89] versus 13.6 [8.35], <jats:italic>p<\/jats:italic>\u00a0=\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our open observational study suggests that agomelatine represents a safe and effective treatment option for elderly patients with major depressive disorder and previous SSRIs\u2010induced hyponatremia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2914","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T12:29:01Z","timestamp":1734006541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Agomelatine as Antidepressant Treatment in Elderly Patients With Previous Hyponatremia Due To SSRI Use: Case Series"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-7268","authenticated-orcid":false,"given":"Jos\u00e9 Alfonso. Ontiveros\u2010S\u00e1nchez de la","family":"Barquera","sequence":"first","affiliation":[{"name":"Departamento de Psiquiatr\u00eda Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Alberto De la Garza","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatr\u00eda Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1022-7077","authenticated-orcid":false,"given":"Guillermo","family":"S\u00e1nchez\u2010Torres","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatr\u00eda Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andoni","family":"Gogeascoechea\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatr\u00eda Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Jezzini","family":"Martinez","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatr\u00eda Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo A.","family":"Porras\u2010Garza","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatr\u00eda Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Patricio Zarate","family":"Garza","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatr\u00eda Universidad Aut\u00f3noma de Nuevo Le\u00f3n  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta15280"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2014.01.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2024.237"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0000000000000608"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.09.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.591"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850\u2010200209000\u201000004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811211001082"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1092852922000505"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2573"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1091"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2017.09.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.yic.0000195659.99148.09"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7860\/jcdr\/2021\/48204.14641"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.06.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210\u2010200620120\u201000003"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.2914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T12:41:44Z","timestamp":1738068104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.2914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/hup.2914"],"URL":"https:\/\/doi.org\/10.1002\/hup.2914","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"2024-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2914"}}