{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T22:26:14Z","timestamp":1750112774883},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,9,12]],"date-time":"2001-09-12T00:00:00Z","timestamp":1000252800000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paroxetine inhibits cytochrome P<jats:sub>450<\/jats:sub> 2D6, which is involved in the metabolism of mirtazapine. The possible drug\u2010drug interaction between two pharmacologically distinct antidepressants, mirtazapine and paroxetine, has been investigated in a randomized, three\u2010way crossover study in 24 healthy male and female subjects. After a titration phase of 3 days, each subject received single daily doses of 30\u2009mg mirtazapine, 40\u2009mg paroxetine or the combination for 6 days. Assessments included serial blood sampling for pharmacokinetics at steady state, cognitive testing using the test battery of CDR Ltd, a visual analogue mood rating scale (Bond and Lader) and the Leeds Sleep Evaluation Questionnaire. Paroxetine inhibits the metabolism of mirtazapine, as shown by increases of approximately 17% and 25% of the 24\u2009h AUC's of mirtazapine and its demethyl metabolite, respectively. Mirtazapine did not alter the pharmacokinetics of paroxetine. The combined administration of mirtazapine and paroxetine probably does not alter cognitive functioning or result in major changes on the visual analogue mood rating scale and Sleep Evaluation Questionnaire, compared with the administration of either drug alone. The incidence of adverse events was lower during combined administration of mirtazapine and paroxetine than during administration of either drug alone. Fatigue, dizziness, headache, nausea, anxiety and somnolence were the most common adverse events during combined administration. These data suggest that the combination of mirtazapine and paroxetine is unlikely to lead to clinically relevant drug\u2010drug interactions and can be used without dose adjustment of either drug. The combination may even be better tolerated than either drug alone. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hup.318","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T01:38:50Z","timestamp":1106617130000},"page":"449-459","source":"Crossref","is-referenced-by-count":17,"title":["Mirtazapine and paroxetine: a drug\u2010drug interaction study in healthy subjects"],"prefix":"10.1002","volume":"16","author":[{"given":"F. J. L.","family":"Ruwe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Smulders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Kleijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. L. A.","family":"Hartmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M. A.","family":"Sitsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,9,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.150.11.1737"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(00)00069-9"},{"issue":"4","key":"e_1_2_1_4_1","first-page":"19","article-title":"The pharmacological profile of mirtazapine","volume":"57","author":"de Boer T","year":"1995","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1974.tb02285.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532008"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199713010-00005"},{"key":"e_1_2_1_8_1","first-page":"21","article-title":"Paroxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness","volume":"41","author":"Dechtant KL","year":"1991","journal-title":"Drugs"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199206004-00012"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979550"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00191912"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199957040-00010"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1989.tb07176.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199207020-00007"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809502901215"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-199605040-00006"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(98)00460-5"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6394(1996)4:4<169::AID-DA3>3.0.CO;2-A"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700014379"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00434408"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200010000-00006"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199508000-00005"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.470100904"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280000174"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988110001400207"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199513020-00004"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199733060-00004"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038060-00001"},{"key":"e_1_2_1_29_1","first-page":"91","article-title":"The effects of moclobemide on cognition","volume":"29","author":"Wesnes K","year":"1989","journal-title":"J Neural Transm"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v59n0606"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.318","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T10:57:31Z","timestamp":1700305051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1002\/hup.318"],"URL":"https:\/\/doi.org\/10.1002\/hup.318","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}