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Twenty\u2010four volunteers, 15 females and 9 males, were assigned to infusion with either placebo or CCK\u20104 in a randomized, double\u2010blind, parallel group design. ERPs, elicited within a standard auditory odd\u2010ball paradigm requiring the counting of rare (20%) occurring \u2018deviant\u2019 tones interspersed among more frequent (80%) occurring \u2018standard\u2019 tones, were assessed once before infusion, and at 10\u2009min and 40\u2009min after the onset of infusion. Compared with the placebo, CCK\u20104 delayed the latencies of N100 and P200 components elicited by \u2018deviant\u2019 stimuli. No significant treatment differences were observed with respect to N200, P300b, mood or adverse symptoms. These preliminary findings suggest that CCK\u20104 may interfere with information processing relating to the selection of significant stimuli and as such, may be of relevance to mechanisms underlying panic disorder. 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