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Eighteen smokers (<jats:italic>n<\/jats:italic>\u2009=\u200918) were evaluated while smoking freely and after 24\u2009h of nicotine abstinence. Immune, cardiovascular and psychological measures were collected. Hunger, nervousness, anxiety, restlessness and irritability increased during abstinence (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); systolic blood pressure and heart rate levels decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Analysis demonstrated a split among smokers in response to abstinence compared with smoking freely; some smokers (<jats:italic>n<\/jats:italic>\u2009=\u200910) displayed increased C\u2010reactive protein (CRP, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) whereas others (<jats:italic>n<\/jats:italic>\u2009=\u20098) responded with decreased CRP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). An increase in symptoms of depressed mood and a fall in heart rate occurred only in those who displayed increased CRP with nicotine abstinence ( <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), while systolic blood pressure fell only in those whose CRP levels decreased with abstinence ( <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Interleukin\u20101 and interleukin\u20106 did not change with abstinence. The results suggest that 24\u2009h nicotine abstinence does not stimulate inflammation among all smokers, but that a sub\u2010group of smokers do demonstrate an inflammatory response with significant negative psychological and physiological symptomatology. 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